Background: Acne is chronic inflammatory disease with formation of papules, pustules, and nodules. Vitamin-D is fat soluble vitamin with immunomodulatory function, helps reducing inflammation. Objectives: assess frequency of serum vitamin-D deficiency among acne vulgaris patients and the effect of vitamin-D supplementation on acne grading. Method: the study was conducted on two phases, phase I was a cross-sectional study included measuring serum vitamin D level for 80 acne patients attending dermatology clinic at Menoufia University Hospital. Phase II was an interventional case control study where studied acne patients with vitamin-D deficiency (66 patients) were randomly divided into two groups; one group (33 patients) were treated with free Oral vitamin-D 2000IU/ tablet daily for two months in addition to regular acne treatment. The other group (33 patients) received traditional treatment for acne without vitamin-D supplementation and both groups were followed up clinically for two months. Results: frequency of vitamin-D deficiency among studied patients was 82.5%, there was statistically significant relation between vitamin-D deficiency and severity of acne as 27.3% and 9.1% of them had grade 3& 4 acne respectively versus 7.1% and zero% among acne patients with normal vitamin D. Vitamin-D deficiency is significantly prevalent among female patients (98.4%), there was significant improvement in acne grading after vitamin-D supplementation. Conclusion: There is a significant relation between vitamin-D deficiency and severity of acne vulgaris and vitamin -D has a good role in management of acne. So. It is recommended to evaluate the serum level of vitamin D in acne patients and provide vitamin D supplementation to vitamin D deficient patients beside topical treatments for acne.

Background: Laparoscopic Cholecystectomy is one of the most common surgical procedures. Quality of life (QOL) is a concept reflecting physical, social, and emotional attitudes. Surgical operation, as a traumatic treatment procedure, could affect QOL of the patients as well as treating them. Therefore, surgeons should try their best to improve patient's QOL in addition to focus on the more traditional outcomes of mortality, morbidity, and laboratory findings. Objectives: The aims of the current work were to determine risk factors for calcular cholecystitis and assess the determinants of quality of life after laparoscopic cholecystectomy. Patients and methods: This cross-sectional study included a total of 200 patients prepared for laparoscopic cholecystectomy, attending at

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