Background: Acute myocardial infarction (AMI) is usually caused by rupture of an atherosclerotic plaque leading to thrombotic occlusion of a coronary artery. Cardiovascular disease has recently emerged as the leading cause of death during hajj. Our aim is to demonstrate the AMI pilgrim's related disparities and comparing them to non-pilgrim patients. Result: Out of 3044 of patients presented with AMI from January 2016 to August 2019, 1008 (33%) were pilgrims. They were older in age (P < 0.001) and showed significantly lower rates cardiovascular risk factors (P < 0.001 for DM, smoking, and obesity). Pilgrims were also less likely to receive thrombolytic therapy (P < 0.001), show lower rate of late AMI presentation (P < 0.001), develop more LV dysfunction post AMI (P < 0.001), and have critical CAD anatomy in their coronary angiography (P < 0.001 for MVD and = 0.02 for LM disease) compared to non-pilgrim AMI patients. Despite AMI pilgrims recorded higher rate of primary percutaneous coronary intervention (PPCI) procedures, they still showed poor hospital outcomes (P < 0.001, 0.004, < 0.001, 0.05, and 0.001, respectively for pulmonary edema, cardiogenic shock, mechanical ventilation, cardiac arrest, and in-hospital mortality, respectively). Being a pilgrim and presence of significant left ventricular systolic dysfunction, post AMI was the two independent predictors of mortality among our studied patients (P = 0.005 and 0.001, respectively). Conclusion: Although AMI pilgrims had less cardiovascular risk factors and they were early revascularized, they showed higher rates of post myocardial infarction complication and poor hospital outcomes. Implementation of pre-hajj screening, awareness and education programs, and primary and secondary preventive measures should be taken in to consideration to improve AMI pilgrim's outcome. Background Acute myocardial infarction (AMI) is usually caused by interaction of lipoprotein retention, inflammatory process, and rupture of an atherosclerotic plaque leading to thrombotic occlusion of a coronary artery. It is classified into ST-elevation myocardial infarction (STEMI) and non ST-elevation myocardial infarction (NSTEMI). These patients are generally treated with combination of medical therapy and revascularization with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) [1, 2]. Hajj is a great event, and it is one of the five Islamic pillars. Millions of pilgrims from different countries of the world come to the kingdom of Saudi Arabia for performing hajj. The overcrowding, hot climate, and huge physical stress expose the pilgrims to many health hazards. Cardiovascular disease has recently emerged as the leading cause of death during hajj [3, 4].

Background: Alteration in sensory perception that occurs during anti neoplastic chemotherapy can seriously affect the health and nutritional status of patients, everyday life activities and recovery possibilities. Aim: This study aimed to assessment of sensory perception alteration for patients receiving anti neoplastic chemotherapy. Subjects and method: Across section study design using a mixed-methods study combining qualitative and quantitative approaches of data collection was adapted. A convenient sample from patients receiving anti neoplastic chemotherapy that were available within 6 months.The present study included a group of 100 Cancer patients receiving ACH. Data were collected through Sensory administrated questionnaire for quantitative data and interview schedule for qualitative data collection. Results: The majority of the patients in the study displayed alteration of taste perception reported the highest mean value (66.35) followed by sense of tactile perception alteration (57.54) then visual perception alteration(45.41) followed by hearing perception alteration (39.81) then sense of position perception alteration(37.97) and finally was sense of smell perception alteration (34.61) ,there are statistically significant relation between sense of vision and sense of tactile perception alteration with the starting date of ACH at p value ˂ 0.05. Also, six themes were identified in the current study which reported that more than half of patients express taste perception alterations. Recommendations:conducting educational programs to improve patient's knowledge and a wariness regarding receiving of ACH. Conclusion: Sensory perception alterations during ACH are significant complaints of cancer patients. In addition to reducing life satisfaction, poor compliance and even decreased response to therapy.

Foodborne diseases and poisoning are widespread in the world. It is a potential threat to human health. This study aimed to investigate alternative antibacterial compounds from actinomycetes isolated from medicinal plants in Sinai, Egypt, against multidrug-resistant foodborne microorganisms (Salmonella spp. and Staphylococcus aureus). Bacteria are found in meat. A total of 100 randomly selected meat samples from the governorate of Port Said were obtained for this study. Out of those, 16% were found contaminated with S. aureus, while 7% were found contaminated with Salmonella. Susceptibility testing of the isolates to 12 antibiotics was performed using the Kirby-Bauer modified disc diffusion technique. All the S. aureus and Salmonella isolates were confirmed resistant to at least two antibiotics. About 100 % of S .aureus isolates were resistant to Ceftriaxone, 81.25% were resistant to Ampicillin, 75% were resistant to Oxytetracycline, while 100 % of Salmonella isolates were resistant to Erythromycin, and 85.7% were resistant to Rifampicin. Two of the S. aureus isolates showed multidrug-resistant to 6 antibiotics out of 12 antibiotics tested. One of the Salmonella isolates was also found resistant to 5 antibiotics out of 12 antibiotics tested. A total of 41 extracts from endophytic actinomycetes were screened for antibacterial activity against S. aureus and Salmonella which are multidrug-resistant. Out of 41 actinomycetes extracts 11 showed high antibacterial activity against the isolated foodborne pathogens (S. aureus and Salmonella). Results of the present study have shown that the antimicrobial compound derived from extracts of the endophytic actinomycetes may be useful in developing antibiotics against multidrug-resistant bacteria.

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