Tuberculosis (TB) is one of the oldest known human diseases and is still one of the biggest killers of infectious diseases that kill five thousand people every day. New drugs are needed to stem the TB epidemic by studying the synthesis of complex compounds that can be developed as anti-tuberculosis agents. Two new complexes of dithiocarbamate, methyl isobutyl dithiocarbamate zinc(II) and methyl isobutyl dithiocarbamate phenanthrolinetellurium(IV) were synthesized using an 'in situ' method by reaction complexes in a 1:1:3 molar ratio in refluxing ethanol. The complexes were characterized by using Ultra Violet Visible (UV-Vis), Fourier Transform Infra Red (FT-IR), Nuclear Magnetic Resonance (NMR), conductivity, and melting point. The result UV-Vis to methyl isobutyl dithiocarbamate Zn(II) and methyl isobutyl dithiocarbamate phenanthroline-tellurium(IV) each of them is 212 nm and 211 nm electronic transition is π → π* of CS2 and N=C=S. Infra-Red absorption spectra at wave number Zn(II) methyl isobutyl dithiocarbamate 374 nm-1 and methyl isobutyl dithiocarbamate phenanthroline-tellurium(IV) 364 nm-1 is coordination occurred dithiocarbamate ligands and atoms M=S. 13 C NMR (ppm) spectra Zn(II) methyl isobutyl dithiocarbamate 20.1, 28.0, 43.3, 64.5. 1 HNMR (ppm) 0.976 (d), 0.962 (d), 2.3 (m), 3.770 (d), 3.455 (s), 3.755 (d) and 13C NMR (ppm) methyl isobutyl dithiocarbamate phenanthroline-tellurium(IV) 25. 0, 30.3, 64.6, 73.3, 124.0, 126.3, 127.7, 136.9, 146.2, 159.3, 205.0. 1 HNMR (ppm) 2.040 (s), 3.25 (d), 4.25 (m), 2.800 (d), 7.556 (d) 7.713 (s), 8.25 (d). Complex characterization using UV-Vis, IR, and NMR showed that complexes are successfully synthesis. The bio-assay results show these complexes are potential as anti-tuberculosis agents.