A new complex of Zn(II) that contain amino acid valine and dithiocarbamate ligands were synthesized and characterized by using Ultraviolet Visible (UV-Vis), Infra Red (IR) spectroscopy, X-Ray Fluoroscence (XRF), X-Ray Diffraction (XRD), melting point and molar conductance. The complex was prepared by “in situ method” and showed that complexes are successfully synthesis. The invitro cytotoxic complexes compound was examined againts MCF-7 (breast cancer) using cis-Pt drug as a control positive and the complexes exhibit very strong invitro cytotoxic againts MCF-7 based on IC50 data is 639,35 µg/mL which indicates that the complex can induce the morphological MCF-7 cancer cells changes towards apoptosis. Complexes compound were evaluated as their antibacterial agents activity against of mycobacterium tuberculosa H37RV using LJ method and results show these complexes are potential as anti-tuberculosis agents. Therefore this complexes compounds can be use to new drugs compound in the treatment againts of MCF-7 and tuberculosis.
Tuberculosis (TB) is caused by the infection with the bacterium Mycobacterium tuberculosis (M.tb), and according to the World Health Organization, was responsible for 1.6 million deaths and the emergence of 9.6 million new cases in 2017. A serious problem worldwide in the fight against TB is the rapid spread of the multidrug-resistant (MDR) TB due to inconsistent for protracted periods of treatment and the lack of new drugs in the market. New and effective drugs are needed for the treatment of tuberculosis by studying the synthesis of complex compounds that can be developed as anti-tuberculosis agents. A new complexes of dithiocarbamate, Zn(II) phenylalanine dithiocarbamate ligand were synthesized using an ‘in situ’ method by reaction complexes in a 1:2 molar ratio in refluxing ethanol. The complexes were characterized by using Ultra Violet Visible (UV-Vis), Fourier Transform Infra Red (FT-IR), HNMR, XRD, conductivity, and melting point. Complex Zn(II) each of them is 260 nm and 431 nm electronic transition is π → π* of CS2 and N-C-S. Infra-Red absorption spectra at wave number Zn(II) phenylalanine dithiocarbamate is 372nm-1 coordination occurred dithiocarbamate ligands and atoms M=S. Complex characterization using UV-Vis, IR, and HNMR showed that complexes are successfully synthesis. The bio-assay results show these complexes are potential as anti-tuberculosis agents.
The importance of essential metal ions and their metal complexes in the creation of prospective medical therapies has long been recognized. In chemistry, molecular biology, and medicinal fields; the interaction of metal complexes with DNA has been a subject of study. The dithiocarbamate essential metal complex is described extensively in the literature for its various benefits and advantages. With proper use of ligands, it is proven to increase the cytotoxic activity of metal complexes against cancer cells. Some researches have shown significant progress regarding the biological activities of the dithiocarbamate essential metal complex as antimicrobial, antioxidant, and anticancer agents. Metal complexes form complexes with dithiocarbamate ligands with unique structural variations. In this study, we presented an overview of the cytotoxic effects of some dithiocarbamate essential metal complexes on cancer cells, as well as fresh approaches to the design of essential metal-based therapeutics containing dithiocarbamate and molecular targets in cancer therapy. This review may provide an update on recent developments in the medicinal use of essential metals with dithiocarbamate ligands, carried out to identify recent relevant literature. Finally, we predict that the essential metal complexed with dithiocarbamate can be a new breakthrough in the future development of cancer drugs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.