The peripheral blood smear (SADT) is a human blood cell that is made smear and then stained in a hematology examination to assess various elements of peripheral blood cells such as erythrocytes, leukocytes and platelets. One guarantee of the validity of the results of the SADT examination is the quality of the SADT coloring. This study aims to investigate blood morphology in thin blood smears using anthocyanin extract from purple sweet potato as a natural dye for Giemsa dye. This research is an experimental laboratory by treating and comparing the morphological features of blood (erythrocytes, platelets and leucocytes) in thin blood smears using giemsa staining and using alternative staining of anthocyanin extract from purple sweet potato. Samples in the study using venous blood collected in a vacuum tube using EDTA anticoagulant were then made as a thin blood smear preparation. The results of this study indicated that only erythrosies had a fairly good staining quality, while the quality of the platelets and leucocytes was not good. The morphology of erythrocyte cells that are round or oval and from the side is like a disc (bikonkaf) with a central acromia (pale color). Furthermore, several abnormalities of erythrocyte cell are obtained such as elliptocytes (ovalocytes), schistocytes (helmet cell) and burr cell so that the anthocyanin extract in purple sweet potato has the potential as an alternative stain for erythrocyte cells in peripheral blood smears.
Nanotechnology explores nanoscale materials that can be used in a wide range of industries such as biotechnology, cosmetics, drug delivery, nanomedicine, and biosensors. Nanoparticles in diverse shapes and sizes can be prepared through physical, chemical, and biological methods. The employment of reducing agents, which will change their form, size range, level of stability, and interaction, is a crucial part thus employing a biological approach is necessary. Chemically generated metal oxide nanoparticles raise considerable issues owing to the usage of hazardous and poisonous chemicals, as well as the potential for conservational impairment. In contrast, the production of silver nanoparticles using the principal method of green synthesis has found a special place in research that is considered more environmentally approachable requiring the use to produce non-toxic nanomaterials. Plants and polymer materials have received a lot of interest in the preparation of nanoparticles since they are renewable and affordable. In this review, we present a comprehensive overview of more ecologically friendly synthesis techniques that use plant extracts to make silver nanoparticles and their application as antibacterial agents, as well as toxicity features based on the shape, size range, and phytochemical mechanism of plants.
The importance of essential metal ions and their metal complexes in the creation of prospective medical therapies has long been recognized. In chemistry, molecular biology, and medicinal fields; the interaction of metal complexes with DNA has been a subject of study. The dithiocarbamate essential metal complex is described extensively in the literature for its various benefits and advantages. With proper use of ligands, it is proven to increase the cytotoxic activity of metal complexes against cancer cells. Some researches have shown significant progress regarding the biological activities of the dithiocarbamate essential metal complex as antimicrobial, antioxidant, and anticancer agents. Metal complexes form complexes with dithiocarbamate ligands with unique structural variations. In this study, we presented an overview of the cytotoxic effects of some dithiocarbamate essential metal complexes on cancer cells, as well as fresh approaches to the design of essential metal-based therapeutics containing dithiocarbamate and molecular targets in cancer therapy. This review may provide an update on recent developments in the medicinal use of essential metals with dithiocarbamate ligands, carried out to identify recent relevant literature. Finally, we predict that the essential metal complexed with dithiocarbamate can be a new breakthrough in the future development of cancer drugs.
This research tested the bioactive by using rawfruits of Sapodilla Sapota (Manilkara zapota) as a drag growthmedia of Salmonella Typhi bacteria causes typhoid fever disease.Salmonella typhi is a species of bacteria that are gram-negativebacilli shaped, facultative, aerobic, and moving with a singlePertrich. Sapdilla Sapota has antimicrobial activity againstSalmonella typhi, because it contains a variety of secondarymetabolite compounds such as Saponins, Tannins andFlavonoids. The purpose of this research was to know howefective the raw fruits of sapodilla sapota (Manilkara Zapota)against the growth of Salmonella typhi. This is a laboratoryyresearch by using diffusion test method. The sample of thisresearch is to extract the fruit of Sapodilla Sapota (ManilkaraZapota) crude. The results of this research are 35%concentration of extract cannot be formed drag zone (0 mm), butin 40, 45, 50 and 55% of concentration there are had drag zone (9mm, 13 mm, 13.5 mm, and 18 mm). This can be said that the rawfruit of Sapodilla Sapota extract can inhibit the growth ofSalmonella Typhi bacteria can be done, then the next extension tothe sufferers of the disease typhus to consume raw fruits ofSapodilla Sapota so that can reduce the growth of bacteria.
Penularan vektor nyamuk menimbulkan tiga akibat yaitu ; kesakitan, kecacatan dan kematian. Salah satu cara memutuskan rantai vektor ini, dengan menggunakan larvasida alami yaitu dengan menggunakan bahan tanaman. Manfaat tanaman Allamanda yang dapat digunakan sebagai larvasida alami karena mengandung beberapa senyawa kimia terutama alkaloid, flavonoid, saponin dan tanin yang dapat memberikan pengaruh terhadap mortalitas jentik nyamuk. Jentik nyamuk meliputi Aedes, Culex dan Anopheles. Penelitian ini yaitu untuk mengetahui keefektifan ekstrak daun Allamanda dalam membasmi jentik nyamuk. Jenis penelitian ini penelitian ini adalah observasi laboratorik yang bersifat deskriptif dan tipe penelitian post test-only non equivalent control group group yakni dengan menganalisa keefektifan ekstrak daun allamanda terhadap mortalitas jentik nyamuk, dengan menggunakan daun Allamanda cathartica L. yang di ekstraksi dengan metode maserasi kemudian dibagi menjadi konsentrasi 5%, 15%, 25%, 35%.Hasil yang diperoleh terdapat jentik nyamuk Aedes sp dan Culex sp yang mati pada setiap konsentrasi, semakin tinggi konsentrasi semakin banyak jentik nyamuk yang mati. Ekstrak daun Allamanda memiliki pengaruh terhadap mortalitas jentik nyamuk dengan konsentrasi tinggi lebih efektif dalam membunuh jentik nyamuk. Dimana konsentrasi ekstrak daun berbanding lurus dengan kematian yang dihasilkan. Kata Kunci : Ekstrak Daun Allamanda, Mortalitas, Jentik Nyamuk
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