The current study aimed to know the protective role of the cold aqueous extract of Moringa seeds against the toxic damages caused by levofloxin in male albino rats by studying biochemical parameters. 24 male white rats were randomly divided into four groups, comprising (6 animals per group). The first group (G1) as a control group was dosed orally and daily with physiological solution for 30 days, the second group (G2)) was dosed with levofloxacin at a concentration of 10 mg / kg of body weight, the third group (G3) was dosed with aqueous extract of Moringa oleifera seeds at a concentration of 350 mg / kg The fourth group (G4) was dosed with aqueous extract of Moringa oleifera seeds 350 mg/kg 4 hours before the administration of levofloxacin at a concentration of 10 mg/kg body weight. Male rats in all study groups were administered orally via the dosing tube, with one dose per day for 30 days. . Blood samples were collected in the four groups after one month of dosing to measure the level of Malona dialdehyde and glutathione, as well as the levels of liver enzymes aspartate transaminase (AST), alanine transaminase (ALT) and alkalinephosphatase (ALP).
Objective The goal of this study is to find out how effective Moringa seed (Moringa oleifera) aqueous Extract is in protecting liver tissue from oxidative stress caused by levofloxacin drug . Methods: 24 male albino rats were placed into four groups at random, with six rats in each group being treated for 30 days: Group 1 was a control group, whereas Group 2 was given levofloxacin at a dosage of 10 mg/kg orally by gavage. , The third group received aqueous extracts of Moringa seeds 650 mg/kg, while the fourth group received aqueous extracts of Moringa seeds 650 mg/kg dose before 4 hours of receive orally at a 10 mg/kg per day dose . Results: The albino rat was considerably protected from levofloxacin-induced liver damage when given the aqueous extract Moringa seeds orally at a concentration of 650 mg/kg body weight. The action of the extract also protected the liver damage caused by the medication, which was indicated by congestion central vein degeneration hepatic cell, necrosis hepatic cell, irregular hepatocyte organization, dilatation and congestion of portal vein , Expandation of sinusoids and increased infiltration of inflammatory cells on histological examination.
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