This study was conducted to investigate the effects of sesame seed on the growth and development of mammary glands in white females rats during the stages of (virginity, pregnancy and lactating), where the effect of 30% sesame seed on the growth and development of mammary glands was studied for 20 days. Sixty-three female Albino rats were randomly divided into three groups (virgins, pregnant and lactating) 12 rats / for each group, the three main groups were subdivided into secondary groups (control and treatment) with 6 rats / for each group. Then toe parameters were conducted including: Histological and histochemical studies for each group and through these studies the following results were obtained: Histological specimens stain with hematoxylin and eosin stains revealed that the virgins treated with sesame seeds showed an increase in the number of the lobules filled with large numbers of expansive alveoli compared to the control group. In the pregnant groups, the lobules filled with alveoli were observed in larger numbers and diameters. In the lactation groups, the lobules are more numerous and the alveolus were more expansive and numerous in comparison with the control group. The histochemical studies of the Periodic Acid Schiff (PAS) stain showed a positive intra-alveolar reaction in the mammary glands tissue for each animal of treated and control groups, except the virginity control group which showed a negative reaction to the stain. Whereas the Trichrome stain, which characterized only the control group of virgins with more density of collagen fibers compared to the rest of the groups which were characterized by a deficiency in the density collagen fiber groups for all stages compared to the control groups. From the current study it can be concluded that the sesame seeds have an effective effect on the growth and development of mammary gland tissue
Background: Plants are highly rich in phytochemicals being used to treat various conditions, and a rich source of polyphenols is Spearmint (Mentha spicata L). Such polyphenols have demonstrated multiple bioactivities. This study aims to investigate the effects of the intake of hot-aqueous extracts of spearmint leaves on mammary gland development and growth Method: Thirty six female rabbits were divided into two main groups (18 rabbits/group): (virgin and lactating). Each group was further subdivided into three subgroups (Control, Ovariectomized (OVX) and Spearmint, (6 rabbits/group).All three groups tissues were examined for histological, histochemical and biochemical enzymatic analysis.Result: Spearmint-treated ovariectimized virgin animals demonstrated an increase in the size of lobules that affected the alveolar bud. In the ovariectimized lactating group treated with spearmint, it was shown that the lobules were enlarged and produced more branching alveoli. The stain (PAS) and ALP showed positive reaction in the spearmint group treated with lactation. Conclusion:The hot methanol extract of the spearmint Mentha spicata leaves have a beneficial effect on mammary gland growth and development.
The current study aimed to know the protective role of the cold aqueous extract of Moringa seeds against the toxic damages caused by levofloxin in male albino rats by studying biochemical parameters. 24 male white rats were randomly divided into four groups, comprising (6 animals per group). The first group (G1) as a control group was dosed orally and daily with physiological solution for 30 days, the second group (G2)) was dosed with levofloxacin at a concentration of 10 mg / kg of body weight, the third group (G3) was dosed with aqueous extract of Moringa oleifera seeds at a concentration of 350 mg / kg The fourth group (G4) was dosed with aqueous extract of Moringa oleifera seeds 350 mg/kg 4 hours before the administration of levofloxacin at a concentration of 10 mg/kg body weight. Male rats in all study groups were administered orally via the dosing tube, with one dose per day for 30 days. . Blood samples were collected in the four groups after one month of dosing to measure the level of Malona dialdehyde and glutathione, as well as the levels of liver enzymes aspartate transaminase (AST), alanine transaminase (ALT) and alkalinephosphatase (ALP).
Objective The goal of this study is to find out how effective Moringa seed (Moringa oleifera) aqueous Extract is in protecting liver tissue from oxidative stress caused by levofloxacin drug . Methods: 24 male albino rats were placed into four groups at random, with six rats in each group being treated for 30 days: Group 1 was a control group, whereas Group 2 was given levofloxacin at a dosage of 10 mg/kg orally by gavage. , The third group received aqueous extracts of Moringa seeds 650 mg/kg, while the fourth group received aqueous extracts of Moringa seeds 650 mg/kg dose before 4 hours of receive orally at a 10 mg/kg per day dose . Results: The albino rat was considerably protected from levofloxacin-induced liver damage when given the aqueous extract Moringa seeds orally at a concentration of 650 mg/kg body weight. The action of the extract also protected the liver damage caused by the medication, which was indicated by congestion central vein degeneration hepatic cell, necrosis hepatic cell, irregular hepatocyte organization, dilatation and congestion of portal vein , Expandation of sinusoids and increased infiltration of inflammatory cells on histological examination.
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