Objective: Cytomegalovirus (CMV) is a virus that can be transmitted to a developing child before birth. For most healthy persons who acquire CMV after birth, there are few symptoms. Once a person becomes infected, the virus remains alive, but usually dormant within that person's body for life. There are two different types of infection: primary CMV and recurrent CMV infection. Primary infection can cause more serious problems in pregnancy than recurrent infection can. However, if a person's immune system is seriously weakened in any way, the virus can become active and cause CMV disease. The aim of this study is to evaluate CMV infection, antisperm antibodies in infertile women and its relation to other parameters. Method: Fifty infertile women who presented at the Infertility Clinic of Kammal Al-Sammaree Hospital from May 2008 to July 2009 and thirty fertile control group were included in this study. CMV IgG and IgM measurements were performed by ELISA and antisperm antibody was measured by immunofluorescence test. High vaginal and cervical swabs taken for wet mount, Gram stain and culture. Results: There was no significant difference between infertile and control group regarding CMV IgG. The presence of CMV IgG in the serum was significantly related with previous genital infection of infertility (p<0.001) and previous abortion (p=0.032). Seropositive CMV IgG did not reflect a significant relation with leukocytes number, type of bacteria and antisperm antibody. Conclusion: CMV IgG was detected in infertile women and had no significant relation with antisperm antibodies and other parameters.
-Background -Gastroesophageal reflux disease (GERD) is characterized by diverse symptoms. There is an evidence for a genetic component to GERD as supported by familial aggregation of this disease. Objective -To investigate whether certain human leucocyte antigen genes HLA-DRB1 are associated with GERD. Methods -Patients and controls were prospectively recruited from GIT center at Al-Kindy Teaching Hospital (Baghdad-Iraq)
Background: Background: Helicobacter pylori is an important gastrointestinal bacteria related to the development of superficial atrophic gastritis, peptic ulcer and gastric cancer. Human leukocyte antigens (HLA) may play an important roles in host immune responses to H pylori antigens. Aim of the study: to investigate the association between HLA-DRB1 genotypes and superficial gastritis with H. pylori infection in an Iraqi patients. Patients and methods: Sixty patients with superficial gastritis and 100 individuals with apparently normal results after endoscopic examination were recruited from Al-Kindy Teaching Hospital - Gastrocolonoscope Unit between January 2014 and July 2016. All study patients and controls group underwent upper gastrointestinal endoscopic examinations. They were analyzed for CagA antibodies Immunoglobulin G (IgG) for H. pylori and HLA Class II genotyping (HLA-DRB1). Results: Patients with superficial gastritis with H pylori. The infection showed significant expression (P=0.0001) DRB1*03:01 genotypes and DRB1*15:01 (P= 0.004) as compared to control group. Conclusions: Genetic factor may play a role in gastritis. HLA-DRB1*03 and HLA-DRB1*15 may increased the susceptibility to superficial gastritis in H pylori infected patients.
Background: Ear infections can manifest in many forms depending on site of infection whether external, middle or internal ear and the culprit pathogen whether viral, bacterial or fungal. Acute middle ear infections are usually accompanied by aural discharge. Objective: 1. To get an overview on the bacterial pathogens involved in ear infections. 2. To assess the antibiotic resistance of bacterial pathogens. Methods: A cross sectional study conducted in Al-Kindy Teaching Hospital / Baghdad /Iraq. Swabs taken from 225 patients suffering from aural discharge were tested for culture and sensitivity for the duration of two years 2018-2019. Aural discharge is cultured by inoculating it into blood, MacConkey agar, chocolate agars and Sabouraud agar (for fungi). Then the antibiotic susceptibility and resistance is assessed by (Kirby-Bauer Method). Results: Then, by analyzing the percentage of pathogens involved in ear infections we have found that the highest percentage is for Pseudomonas aeruginosa (51%), followed by Staph, aureus (20%), Proteus vulgaris (11%). Discussion: Cefotaxime, which was known to be an efficient antibiotic against pseudomonas previously, has lost its effectiveness. Similarly, gentamycin is no longer effective against E.coli. Conclusion: Choosing the proper antibiotic in any bacterial infection is of tremendous importance. However, reassessment of antibiotic resistance profiles is vital and should be regarded as a routine task on regular intervals.
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