A Chemoselective, Acid-Mediated Conversion of Amide Acetal to Oxazole: The Key Step in the Synthesis of Cardiovascular Drug, Ifetroban Sodium.-An optimized route to the precursor (VIII) of the cardiovascular drug ifetroban sodium is reported. The strategy involves a high-throughput and high-yielding sequence for the preparation of the amide acetal (IV) and cyclization of the adduct (VI) to the oxazoline as key step. -(SWAMINATHAN, S.; SINGH, A. K.; LI, W.-S.; VENIT, J. J.; NATALIE, K.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fluoride-Catalyzed Intramolecular Denitrocyclization of Nitrotoluenes to Indanes.-In the reaction of the nitrotoluene (I) with (II) or (V) at room temp. no Michael adduct is isolated, but it cyclizes, possibly via its aci-form and attack of the malonate anion on the activated nitro group, forming (III) and (IV) or (VI). -(LI, W.-S.; THOTTATHIL, J.; Tetrahedron Lett. 35 (1994) 36, 6595-6598; Bristol-Myers Squibb Pharm. Res. Inst., Chem. Proc. Res., New Brunswick, NJ 08903, USA; EN)
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.