ChemInform Abstract: A Chemoselective, Acid‐Mediated Conversion of Amide Acetal to Oxazole: The Key Step in the Synthesis of Cardiovascular Drug, Ifetroban Sodium.

Abstract

A Chemoselective, Acid-Mediated Conversion of Amide Acetal to Oxazole: The Key Step in the Synthesis of Cardiovascular Drug, Ifetroban Sodium.-An optimized route to the precursor (VIII) of the cardiovascular drug ifetroban sodium is reported. The strategy involves a high-throughput and high-yielding sequence for the preparation of the amide acetal (IV) and cyclization of the adduct (VI) to the oxazoline as key step. -(SWAMINATHAN, S.; SINGH, A. K.; LI, W.-S.; VENIT, J. J.; NATALIE, K.