The specificity anti-Gd of human cold autoagglutinins is characterized using
untreated and enzyme-treated human red blood cells. Gd determinants of human RBC are
resistant to proteases, but are inactivated by neuraminidase (RDE). In contrast, I/i determinants
are not inactivated by proteases or RDE, while Pr(1-3) determinants are inactivated by proteases
and RDE, and Pr(a) determinants are resistant to RDE, but are inactivated by proteases.
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