Two novel cyclodepsipeptides, geodiamolides A (1) and B (2), were isolated from the marine sponge Geodia sp. and their stereostructures determined by X-ray crystallography. The geodiamolides contain a tripeptide unit of two (S)-alanines and a (R)-3-halotyrosine joined to a polypropionate unit in an 18-membered ring; the halogens are iodine and bromine in 1 and 2, respectively. 1 and 2 showed some activity against the fungus Candida albicans.

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