(1977) showed that DMF or disulfiram administered (each in doses of 2 mmol/kg) to rats increased the blood acetaldehyde levels of these animals four-and five-fold respectively in response to ethanol (2 g/kg) given 18, but not three, hours later. An equivalent dose of N-methylformamide (MF) raised blood acetaldehydn levels equally, whether given three or 18 h before ethanol challenge. Eben and Kimmerle (1976) have shown that, in volunteers exposed for two hours to an atmosphere containing 50-80 ppm of DMF, blood DMF concentrations were of the order of 9-9 ,tg/ml and had fallen to undetectable levels within six hours. Blood MF over the same period rose from a mean of 2-5 jug/ml to 3-2 ,ug/ml and was still detectable in traces after 30 h.One hundred and two men, at various times over a period of three years, were engaged in running a chemical plant in which DMF was used as a solvent. Shortly after operations began in early 1974 some of the men reported that their customary

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