Lymphocytic Meningo-Encephalitis With Myalgia and Rash

The Enanthem of Glandular Fever

“…acute undifferentiated respiratory disease (Commission on Acute Respiratory Diseases, 1944Diseases, , 1947, influenza (Horsfall, 1952), the typhoid group (Banks, 1949), brucellosis (Spink, 1956), infective hepatitis (Hoagland and Shank, 1946), lymphocytic choriomeningitis (Adair et al, 1953), or any of the recently described benign meningitic or meningoencephalitic illnesses of viral origin (Acheson, 1954;Tyrrell and Snell, 1956;Lyle, 1956;Karzon et al, 1965;Garnett et al, 1957;Rotem, 1957).…”

Virus Meningitis and Encephalomyelitis

“…In Great Britain outbreaks of aseptic meningitis, often associated with a rash, were reported from widely separated parts of the country in 1955 and 1956. Nottingham,2" Lancashire, 22 Wensleydale, Sheffield,23 and many other districts appear to have experienced outbreaks of this kind. Each outbreak had some peculiar feature, but in the main these cases were principally in young children and presented with a sudden onset of fever, headache, nausea, and vomiting.…”

Present Trends in Infectious Diseases

“…It is worth noting that in recent years much of the field work which has established association between a specific virus and various clinical syndromes has been performed by medical men engaged in active general practice. An outstanding example is the work done by Dr. W. H. Lyle (1956), a general practitioner in Newton‐Ie‐Willows, Lancashire, on an epidemic which occurred in his practice. A full account of this has now been published (Lyle 1959) and an annotation in The Lancet (1959) makes the following very pertinent observation: “Lyle's paper shows how much valuable information an alert and enthusiastic general practitioner can gather, almost before the virologist has had time to catch up with events.…”

“…The following year outbreaks occurred in East Anglia (Garnett et al 1957), the virus being isolated from cerebrospinal fluids, throat washings and faeces of patients. In 1956 there were widespread outbreaks (Tyrell & Snell, 1956 ; Lyle 1956 : Rotem 1957 : Boissard et al 1957 : McLean & Cameron 1957 : Galpine et al 1958 : Jamieson et al 1958: Stones 1958). ECHO virus type 9 was at this time widely prevalent throughout Europe (Nihoul & Querin‐Thiry 1957 : Johnsson 1957) and in Canada (Sultanian & Rhodes 1958).…”