From the recently described lipolytically active pituitary g1and fraction P IV we isolated three other fractions with different lipid mobilizing effects. These fractions were checked far their corticotropic activity as ACfH belongs to the most active lipolytic hormones. The applied bioassay for ACfH was based on the determination of the corticosterone increase in the adrenal vein blood of hypophysectomized rats. All of the isolated fractions showed corticotropic activity.Horm Metab. Res. 2: 333-337 (1970) K e y -W 0 r d s: Lipolytic Hormone -Purification Procedure -Corticotropin -ACTH-Bioassay_
In 1957, Jervell & Lange-Nielsen (6) first described the syndrome consisting af congenital deaf-mutism, prolongation of the QT-interval in the electrocardiogram, and syncopal attacks. Later, it was found that QT-prolongation and tachyarrhythmic Adams-Stokes attacks may also occur in patients with normal hearing (12,13). This report concerns a young girl with tachyarrhythmic Adams-Stokes attacks, normal hearing, normal resting QTinterval, and a striking sinus bradycardia. CASE REPORTA 10-year-old girl was referred to the University Hospital because of a cardiac arrhythmia detected during introduction of anaesthesia for tonsillectomy. At the age of 1 1/2 years, an unusually slow pulse was first noted. Since the age of 3 years she had frequent attacks ranging in severity fiom brief dizziness, pallor and nausea to sudden episodes of unconsciousness. These attacks always occurred in connection with physical exercise or excitement. The child was believed to have epileptic seizures and was treated without success with various anticonvulsive medications, even though the electroencephalogram was normal.There is no history of deafness, syncopal episodes or sudden death in the family on either side. The patient's father has a sinus bradycardia of approximately 50 beats/min. He and his mother as well as the patient's two brothers show a slightly prolonged QT-interval (QTc 0.43-0.45 sec).The child's physical examination was unremarkable except for a slow heart rate of 50 beats/min. Elec-troencephalogram and routine laboratory studies were normal except for a microhaematuria, for which no cause could be found. On the chest roentgenogram, the heart was of normal size and configuration. The electrocardiogram at rest revealed sinus bradycardia of 48 beatslmin (Fig. 1). The PQ-interval was short (0.12 sec) but still within the normal range. The T-waves were rather flat but there were prominent U-waves as is often seen with bradycardia. The QTinterval was not prolonged (QT 0.45 sec, QTc 0.40 sec, QT ratio 1.00). During exercise on a bicycle ergometer with a load of 50 watts the regular sinus rate rose to 90 to 100 beats/min while the QTc increased up to 0.53 sec and the QT ratio up to 1.32. The U-waves remained prominent. At a heart rate of 90 to 100 beats/min, ventricular arrhythmia regularly developed, either as uni-or multifocal bigemini (Fig. 20) or as short runs of multifocal ventricular beats (Fig. 26) or, on one occasion, as multifocal ( Fig. 3a) and partly bidirectional (Fig. 36) ventricular tachycardia of approximately 200 beats/min. SPECIAL STUDIESRight heart catheterization revealed no evidence of organic heart disease. Electrical stimulation of the superior vena cava-right atrial junction resulted in an atrial rhythm with 1 : 1 conduction to the ventricles up to a frequency of 170 beats/min, when Wenckebach periods appeared. At no time were extra-systoles observed. Up to a frequency of 130 beats/ min the T-waves could be separated from the Pwaves; at this frequency QT was 0.32 sec, QTc 0.47 sec, and the QT ratio 1.18. ...
In recent years it has been frequently reported that not only pathological alterations of the pituitary, hypothalamic centers or the adrenal glands, but also non-endocrine corticotropin producing syndromes lead to Cushing's syndrome. The demonstration of an ectopic ACTH syndrome, however, depends on the determination of ACTH in the tumor tissue. We succeeded in extracting a corticotropic substance from malignant tumors or their metastases. Since bio-and immunoassay of the same tumor extract yielded different results, an atypical ACTH moleeule produced by the tumor was assumed. This was further· supported by the abnormally high stimulation of corticosterone in our patients and the pathologically increased content of MSH. In order to exclude non-specific corticotropic activity, the ACTH content of tumors, metastases and urine were compared with the negative results of normalliver tissue and normal urine.Horm. Metab. Res. 2: 213-220 (1970) K e y -W 0 r d s: Ectopic ACTH Syndrome -ACTH-Extraction -Biological Assay of ACTH -Radioimmunoassay of A CTH
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