Abstract:In recent years it has been frequently reported that not only pathological alterations of the pituitary, hypothalamic centers or the adrenal glands, but also non-endocrine corticotropin producing syndromes lead to Cushing's syndrome. The demonstration of an ectopic ACTH syndrome, however, depends on the determination of ACTH in the tumor tissue. We succeeded in extracting a corticotropic substance from malignant tumors or their metastases. Since bio-and immunoassay of the same tumor extract yielded different r… Show more
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