In both control samples and samples from cases of multiple sclerosis, the B12 concentration in lumbar cerebrospinal fluid was correlated with the concentration in serum. There was no correlation between B12 concentration and total protein in cerebrospinal fluid.A number of estimations of serum B12 were also made with Lactobacillus leichmannii, after extraction in the presence and absence of cyanide. These showed a difference between cases of multiple sclerosis and controls, one interpretation of which might be that the serum in multiple sclerosis contains an abnormally low concentration of hydroxocobalamin.
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