Background:Etoposide is an important chemotherapeutic agent that is used to treat a wide spectrum of human cancers. The efficacy of this drug is often limited due to severe sideeffects such as mucositis, anorexia, myelosupperssion, alopecia. At present there are no anti-mucositic agents without side effects. To combat these side effects of cancer treatment, innovative and specific nutritional interventions are needed. The experimental procedure included an oral treatment with combination of Spondias pinnata and whey preparation (100 mg/kg b.w).on etoposide induced mucositis. Methods: Study was conducted at Central Research Laboratory, Kasturba Medical College. Rats were sacrificed by cervical dislocation and duodenum collected for estimation of biochemical parameters. Estimation was carried out for assessing the levels of TAO, GSH, LPO, NO and activity of MPO. Correlation analysis was performed by one-way Anova using graph pad prism to find the relation between control and test. Result: The antioxidant (TAO and GSH) were found to be significantly high in the rats which received the combination compared to the individual Spondias pinnata and whey treated groups. Administration Spondias pinnata and whey in combination shows significant decrease in the TBARS, NO and MPO levels. Conclusion: Spondias pinnata and whey preparation supplementation in combination have shown mucoprotective effects in rat model. Hence it can be considered as anti-mucositis therapeutic agents which can be safely administered during chemotherapy and can reverse mucositis.
In the recent decade, there have been a lot of significant developments made in the area of Geopolymer concrete. Geopolymer concrete has been proved for its remarkable durability properties but when alterations are done to the conventional geopolymer concrete through the incorporation of fibers, the durability of the fiber reinforced concrete is uncertain. In this analysis, high elasticity modulus and low elasticity modulus fibers were inserted into geopolymer concrete made of M-sand. As ambient curing is favored in this study, geopolymer concrete is GGBS dependent. As an alkali solution, a mixture of sodium hydroxide solution and sodium silicate solution is used. Durability properties such as water absorption, sorptivity, rapid chloride penetration test, resistance to HCL attack, resistance to H2SO4attack, resistance to sulphate and marine attack are determined in this study. Significant observance has been made with respect to different proportions of glass fiber and polypropylene fiber. Glass fibers yielded fairer results compared to the polypropylene fibers. This study reviews the scope of the use of hybrid fibers made of M-sand in Geopolymer concrete.
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