Evaluation of Modulatory Effect of Combination of Spondias Pinnata and Whey Preparation on Intestinal Antioxidants and Inflammatory Markers in Etoposide Induced Rat Model for Mucositis

Vyshnavi,; Rao, Gayathri M; Nayak, Shyamala; Shetty, Beena

doi:10.5530/pj.2018.4.105

Cited by 3 publications

(1 citation statement)

References 22 publications

(24 reference statements)

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“…it has shown significant positive change with oral administration of Spondias pinnata bark extract. [2526] The current study with oral administration of AM fruit pulp in etoposide-induced rat showed significant rise in GSH levels. The GSH level was found drastically low in the rats which received etoposide alone when compared to normal controls.…”

Section: Discussionmentioning

confidence: 73%

Protective potentials of Annona muricata fruit pulp on etoposide-induced gastrointestinal toxicity in Wistar rats

et al. 2019

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BACKGROUND:Mucositis, one of the devastating consequences of chemotherapy and also limits the efficacy of the treatment. At present, there are no antimucositic agents without side effects. Hence, there is a need for better adjuvant therapy using plant or food sources. Here, we have made an attempt to study the effect of Annona muricata (AM) fruit pulp on etoposide-induced mucositis.MATERIALS AND METHODS:The study was conducted at Central Research Laboratory, Kasturba Medical College, Mangalore. The effect of AM fruit pulp (100 mg and 200 mg/kg body weight) on etoposide-induced mucositis was studied in Wistar rats (n = 36) in comparison with normal and AM controls. Intestinal tissue was collected for histology and estimation of total antioxidants (TAO), glutathione (GSH), myeloperoxidase (MPO), and nitric oxide (NO) levels along with histological changes were studied. Statistical analysis was performed by one-way analysis of variance.RESULTS:TAO and GSH levels were found to be significantly high in the rats which received 200 mg of AM/kg body weight than 100 mg of AM/kg body weight when compared with etoposide control. The levels of inflammatory markers - MPO and NO - were found to be decreased (P < 0.001) in the animals received 200 mg/kg body weight of AM in comparison with etoposide group and lower dosage of AM pulp. Histology of intestine also showed a protective effect of AM (200 mg/kg body weight) against etoposide toxicity.CONCLUSION:The results show that AM fruit pulp has the capacity to act as antimucositic agent and also reduced inflammation.

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Section: Discussionmentioning

confidence: 73%

Protective potentials of Annona muricata fruit pulp on etoposide-induced gastrointestinal toxicity in Wistar rats

et al. 2019

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Phytopharmacological and Biological Exertion of Spondias pinnata: (A Review)

2022

Orient. J. Chem

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Herbal medicines are gaining wide recognition and acceptance due to their versatility in usage as condiments, dietary supplements, therapeutics, flavoring agents, etc. Medicinal herbs are a broad reservoir for biological and pharmacological active bio-compounds exhibiting therapeutic activities and can be implemented to diagnose and manage various disorders and ailments. This review emphasizes on the photo assembly and therapeutic properties of Spondias pinnata which is extensively utilized in folklore and traditional medicine. The greater disadvantage of herbal medicine is the scarcity of scientific affirmation of the safety, potency, purity, and dosage of the herbal drug. Spondias pinnata demonstrates various pharmacological properties like antihyperglycemic, anti-cancerous, anti-inflammatory, anti-oxidant, anti-microbial, hepatoprotective, etc. which indicates their potential to address numerous maladies. This review concentrates on the pharmacological effectiveness of Spondias pinnata to provide substantial evidence from past research in order to insinuate this medicinal herb as a potential drug.

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Whey preparation as an adjuvant to minimise the Intestinal inflammatory status in mucositis rat model

Reddy,

M Rao,

Marathe

et al. 2023

RJPT

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To study the effect of Whey Preparation on intestinal mucositis, model developed by administration of single dose of etoposide (60mg/Kg body wt., i.p). The experimental procedure included Adult albino rats (10±1 week old) of Wistar strain (n=30, 6/group). Freshly prepared whey preparation-(100 and 200mg/Kg/body wt.) was administered by orogastric gavage- Pre, both pre and post etoposide injection. Effectiveness of whey preparation was determined by estimating the biochemical parameters including intestinal Tumor Necrosis Factor-α, Interleukin-6, sodium potassium ATPase, inflammatory markers- Cyclooxygenase and Myeloperoxidase along with Nitric Oxide and reduced Glutathione with and without intervention after 72 hrs. of etoposide injection. There was a significant increase in the Tumor Necrosis Factor –α, Interleukin-6 levels and extent of apoptosis in etoposide controls. Etoposide administration caused a significant decreased the activity of Na+-K+ ATPase and reduced glutathione levels in intestinal tissue. However, in the post treatment groups, Tumor Necrosis Factor–α, Interleukin-6 as well as extent of apoptosis were reverted to normal after whey preparation administration.Whey Preparation gavage in both the study groups- pre and both pre and post etoposide exposure showed that intervention was able to preserve/ prevent changes in the biochemical activity. The results support the WP potentials to reduce the deleterious effects of etoposide on normal cells, which leads to mucositis.

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Evaluation of Modulatory Effect of Combination of Spondias Pinnata and Whey Preparation on Intestinal Antioxidants and Inflammatory Markers in Etoposide Induced Rat Model for Mucositis

Cited by 3 publications

References 22 publications

Protective potentials of Annona muricata fruit pulp on etoposide-induced gastrointestinal toxicity in Wistar rats

Protective potentials of Annona muricata fruit pulp on etoposide-induced gastrointestinal toxicity in Wistar rats

Phytopharmacological and Biological Exertion of Spondias pinnata: (A Review)

Whey preparation as an adjuvant to minimise the Intestinal inflammatory status in mucositis rat model

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