The paper reports the results of organizing distant learning of Traumatology and Orthopedics course by Bogomolets National Medical University students of the fifth year of study in the conditions of quarantine. The authors present the experience of using Neuron portal developed on the basis of LMS Moodle in combination with MOOCs and videoconferencing and the results of student survey (N=47) after taking the course. 12-item Likert scale was used to assess students' perceptions of on-line learning. The benefits are course efficiency in obtaining necessary knowledge and skills (61,7%), flexibility (80,85%), developing critical thinking (68,09%), creativity (68,09%), problem-solving skills (74,47%), collaboration skills (93,62%), teacher-student interaction (82,98%), self-directed learning (87,23%), enhancing computer literacy skills (80,85%), impact of distance learning on motivation (55,32%), filling the gap between theory and practice (74,47%). The drawbacks are problems with the Internet (38,3%), lack of digital literacy (12,77%). The research emphasizes the importance of developing collaborative learning skills which is realized by implementing a case-based method in online education, which promotes the development of critical thinking and problem-solving skills. Some recommendations are given for teachers regarding learning process organization. The findings can be used by educators and course developers in Traumatology and Orthopedics in Ukraine and abroad.

The aim of the work is the synthesis and study of the bioactivity of sol-gel glass (BG 60S) with molar composition 60 % SiO2, 36 % CaO, 4 % P2O5 and samples doped with La and Y in vitro; studying their structural properties and changes upon contact with a model physiological environment (Kokubo’s SBF), as well as justifying the possibility of their use for tissue regeneration and tissue engineering. According to the results of research, the interaction of synthesized samples with SBF leads to a change in the phase composition and the ratio of amorphous and crystalline components. It is necessary to note long and intensive processes involving CO32– ions for unalloyed and alloyed samples. The appearance of calcium carbonate in the form of vaterite with a simultaneous increase in the calcite content is one of the signs of high bioactivity of the synthesized samples. According to the results of XRD, EDX and FTIR studies after 28 days of soaking in SBF, the predominant surface elements are Ca and P in the composition of hydroxyapatite, and the elemental composition indicates active ion exchange processes according to the theory of bioactive glass dissolution in physiological fluids. The change in the ratio of crystalline phases with the inclusion of mainly one crystalline phase of hydroxopatite within 28 days leads to a better structuredness of the surface of the synthesized samples and indicates that they have osteoconductive properties, can connect with bone tissue and have the appropriate biodegradation ability. The results of the study indicate the promising nature of synthesized materials for tissue regeneration and tissue engineering.

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The purpose of the work is the synthesis of samples of X-ray luminescent nanodispersed lanthanum phosphate activated with terbium (LaРО4:Tb3+), the study of their structural properties and luminescence spectra when excited by ultraviolet and X-ray radiation, as well as determination of the possibility of their use in nanocomposites with bioactive glass and colloidal nanosystems. Samples of nanocrystalline lanthanum phosphate were synthesized composed of LaPO4·0.5H2O, of hexagonal syngonium, activated with terbium, their structural properties, luminescence spectra were studied upon excitation by UV and X-ray radiation, a possibility was shown to use them in nanocomposites with bioactive sol-gel glass and aqueous colloidal systems. Composites of 60S bioglass with nanodispersed crystalline LaPO4:Tb3+ in the dry state and in distilled water medium demonstrated the presence of luminescence when excited by UV and X-ray radiation. The given data indicate the perspective of nanodispersed phosphors based on lanthanum phosphate, their composites with bioactive sol-gel glass in colloidal systems, for use in optopharmacology and photodynamic therapy of diseases localized in bone tissues. In addition, the results of research can be useful for technical applications, in particular, in the creation of luminescent detectors of high-energy electromagnetic radiation, development of photo- and optoelectronic devices, etc.

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The aim of the work is the synthesis of nanostructures based on lanthanum fluoride, promising for use in photodynamic therapy of tumors in organs of cranial cavity and bone tissues; a study of their structural properties and luminescence spectra. Synthesis of LaF3:Tb3+ was carried out by coprecipitation of components from aqueous and alcoholic (methanol) solution. As precursors were used: La(NO3)3×6H2O, TbCl3, NH4F. All reagents have qualification “chemically pure”. Distilled water and methanol were used as solvent. The synthesis of nanosized magnetite in the single-domain state was performed by the Elmore method. Synthesized nanodisperse samples are characterized by XRD analysis, DTGA, TEM. The magnetic properties and spectra of UV luminescence were also studied. It has been found that the XRD-patterns of LaF3:Tb3+ samples synthesized in water and methanol do not differ fundamentally. Under the experimental conditions, the most perfect crystals of hexagonal syngony were formed during crystallization in an autoclave. Their average size was ~ 15 nm. In TEM images, the length of the crystals exceeds the width by 3–4 times. Crystals are prone to aggregation and the formation of chain structures. The UV luminescence spectrum of the synthesized nanodisperse samples in aqueous medium at the concentration of 0.5 mg/ml and excited by ultraviolet radiation is characteristic of the structure of LaF3:Tb3+. Ensembles of particles Fe3O4/LaF3:Tb3+ NCs were synthesized. Transmission electron microscopy has shown that the shapes of particles of NCs and LaF3:Tb3+ nanocrystals are fundamentally different. Particles of Fe3O4/LaF3:Tb3+ NCs have a spherical shape, which is characteristic of structures of the core-shell type. X-ray diffraction patterns of NCs confirm this conclusion. The conditions for the synthesis of NCs did not significantly change the magnetic properties of their nuclei, single-domain Fe3O4 nanoparticles (NPs). The luminescence spectrum of Fe3O4/LaF3:Tb3+ NCs differs significantly from the spectrum of samples of nanodispersed LaF3:Tb3+ both in intensity and in the structure of the bands. These spectral differences may be due to differences in structure, features of the nanocrystalline structure, the content of the LaF3:Tb3+ scintillator and Tb3+ ions in samples of LaF3:Tb3+ nanocrystals and shells of Fe3O4/LaF3:Tb3+ nanocomposites. Composites of dispersed 60S bioglass with nanodispersed crystalline LaF3:Tb3+ in the dry state, and distilled water, showed the presence of luminescence upon excitation by UV radiation. The results of research show the prospects of the synthesized nanodispersed luminophors LaF3:Tb3+, for use as a source of luminescent radiation in optopharmacology and photodynamic therapy of tumors in organs of cranial cavity and bone tissues. Optimization of luminescent properties of the original nanodispersed luminophors, their compositions with bioactive glass, luminescent shells in the composition of magnetosensitive NCs, as well as the technology of manufacturing of these structures will significantly allow us to improve their performance characteristics. The results of the work indicate the prospects of the synthesized structures for further research under the conditions of excitation by high-permeability “soft” X-ray radiation for use in optopharmacology and photodynamic therapy of tumors in organs of cranial cavity and bone tissues. Optimization of properties of the original nanodispersed luminophors, their compositions with bioactive glass and magnetosensitive carriers Fe3O4 will allow us to improve significantly their performance characteristics.

Проведено порівняльний морфометричний аналіз між показниками фіброретикулярної та кісткової тканини, що сформувалася в дефекті кістки після імплантації біоскла, а також біоскла з уведенням автоплазми, збагаченої тромбоцитами. В серії досліджень із додатковим уведенням автогенної плазми, збагаченої тромбоцитами, виявлено підвищення в дефекті кісткової тканини на 9 % (P < 0,001). Біоскло характеризується остеокондуктивністю й остеоінтеграцією, матеріал біологічно активний, що проявляється формуванням на його поверхні активних остеобластів і кісткової тканини, часткової резорбції остеокластами. Навколо частинок біоскла були відсутні запальні прояви та алергічна реакція, матеріал був сумісний із кістковою тканиною та кістковим мозком. Деструктивних порушень кісткового мозку навколо частинок біоактивного скла не зафіксовано. Локальне введення плазми, збагаченої тромбоцитами, сприяло підвищенню остеоіндуктивних властивостей біоскла в ділянці травматичного пошкодження.