Eco-tourism being one of six groups of OCOP products plays a key role in the rural economic development. However, there are limited empirical evidences on the impacts of destination attributes of OCOP tourism on tourist satisfaction. Thus, the objective of this current study is to investigate the impacts of OCOP eco-tourism destination attributes on tourist satisfaction. The study conducted face-to-face interviews with 200 eco-tourists and employed exploratory factor analysis and multiple regression. The study found that the shared social and environmental responsibilities - core characteristics of OCOP tourism have the highest effect on tourist satisfaction. The study also provides some policy implications for sustainable development of OCOP eco-tourism destinations in the Mekong Delta.