A new, simple method for the extraction of specific interaction enthalpy from the enthalpy of solvation is proposed. It is based on empirical but very general relationships describing the non-specific solvation enthalpy. The specific interaction enthalpy is calculated from the solution enthalpies in the solvent under consideration, cyclohexane and tetrachloromethane. The solution enthalpy of at least one linear alkane in the solvent must also be available. The solution enthalpies of a 'model compound' or homomorph are not required. This method is applicable not only for proton-donor solutes but also for acceptor solutes such as iodine. It can be used also for solvents associated by hydrogen bonding (e.g. alcohols). The enthalpies of specific interaction for 280 solute-solvent systems were calculated. Solution enthalpy data were mainly obtained from the literature and partially measured by the authors. The results were compared with literature data on complexation enthalpy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.