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Thyroid cancer bone metastases identified as part of routine clinical follow-up frequently cause significant and recurrent morbidity. The incidence of SRE and median time to first SRE in metastatic thyroid cancer to bone are similar to those reported in other solid tumors. Prospective clinical trials to assess the efficacy of antiresorptive agents in this population are needed.

Purpose of Review This review addresses our current understanding of the pathogenesis of HIV associated lipohypertrophy, and describes an evidence-based approach to treatment. Recent Findings Although the pathogenesis of HIV associated lipohypertrophy remains elusive, recent clinical and laboratory investigations in fatty acid metabolism and growth hormone dynamics have furthered our understanding of the condition. These findings have also paved the way for new therapeutic interventions, of which tesamorelin, an analogue of growth hormone-releasing hormone, has gained recognition as a promising treatment strategy against visceral fat accumulation. Recent randomized placebo-controlled trials of tesamorelin demonstrated significant reductions in visceral adipose tissue, improvement in lipid parameters, and no adverse effects on glucose tolerance. Optimal therapeutic dosing and treatment duration, though, are not yet known. Whether treatment with GHRH-analogues will translate into improved long-term metabolic and cardiovascular outcomes also remains to be seen. Summary Although the pathogenesis of HIV lipohypertrophy remains unclear, several theories and observations have led to the development of treatment strategies to counter fat accumulation and its accompanying metabolic complications. Based on clinical trials, analogues of the GH/GHRH axis appear to be most effective in reducing visceral adipose tissue.

As the number of Asian American voters has increased with each election, more research is needed to understand the participation and voting patterns of this diverse electorate. This paper offers an analysis of Asian American political participation and vote choice preferences during the 2016 presidential election. The paper begins by addressing the concerns related to Asian American political incorporation. We disaggregate Asian Americans into three voting types—voters, those who are eligible to vote but are not registered, and those who are ineligible to vote—and compare the demographic differences found across these three groups. The second half of the paper turns to Asian American candidate preferences in the 2016 election. We find that voters who report high levels of media consumption and those with a strong sense of political efficacy were more likely to support Clinton. Our analysis of non-voters suggests that the potential incorporation of these Asian Americans would result in a continued base of support for the Democratic party.

Participants with diabetes have various options for weight loss. Dietary interventions with either low-carbohydrate or low-fat diets may lead to some improvements in QOL in patients with type 2 diabetes.

Background: Since the start of coronavirus disease 2019 (COVID-19) pandemic, several studies have linked obesity with severity of illness as well as mortality in patients with COVID-19. Outcomes of patients with overweight or obesity, who develop critical illness, have been studied extensively over the past decade where the studies have shown conflicting results. In this study, we aimed to assess the association between the body mass index (BMI) classes and outcomes among hospitalized patients with COVID-19.Methods: This was a retrospective chart review of all adults admitted to our hospital with COVID-19 illness between 1 March 2020 and 30 June 2020. Patients were divided into four groups based on their BMI range as follows: patients with underweight (BMI < 18.5 kg/m 2 ), patients with normal weight (BMI 18.5-24.9 kg/m 2 ), patients with overweight (BMI 25-29.9 kg/m 2 ), and patients with obesity (BMI ≥ 30 kg/m 2 ).Results: 1274 patients were admitted during the study period. There were 24(1.9%) patients with underweight, 268 (21%) patients with normal weight, 445 (34.9%) patients with overweight, and 537 (42.2%) patients with obesity. Patients with obesity were younger (p < 0.001) and there were more females among patients with underweight and patients with obesity (54% and 48% respectively, p < 0.001).There were no differences in subgroup with regards to presence of hypertension, diabetes mellitus, coronary artery disease, congestive heart failure, and dyslipidemia. In a multivariate logistic regression model, patients with overweight and patients with obesity had higher odds of requiring mechanical ventilation. BMI class was not associated with difference in survival time in a multivariate analysis. Conclusions:In our large single-center study of hospitalized patients with COVID-19, patients with overweight and obesity had higher need for mechanical ventilation but had similar mortality when compared to patients with normal weight and underweight.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Hyperglycemia has long been recognized to have detrimental effects on postoperative outcomes in patients undergoing surgery. The manifestations of uncontrolled diabetes are manifold and can include risk of hyperglycemic crises, postoperative infection, poor wound healing, and increased mortality. There is substantial literature supporting the role of diligent glucose control in the prevention of adverse surgical outcomes, but considerable debate remains as to the optimal glucose targets. Hence, most organizations advocate the avoidance of hypoglycemia while striving for adequate glucose control in the perioperative period. These objectives can be accomplished with careful preoperative evaluation, clear patient instructions the day of surgery, frequent blood glucose monitoring during the perioperative period, and use of effective strategies for insulin initiation and titration. This article highlights the major issues concerning patients with diabetes undergoing surgery and reviews the management recommendations put forth by general consensus guidelines and expert opinion.

The diversity of the Asian American population presents challenges for theories of bloc voting, partisan voting, and descriptive representation. What cues (if any) do Asian American voters rely on? How informative are racial and partisan cues to Asian American voters. This article looks at the candidate preferences of Asian American voters in the 2018 election. I look at elections where an Asian American candidate was on the ballot and compare outcomes within district to the gubernatorial race (a race with no minorities on the ballot). I use surname-coded voter registration records and precinct-level vote returns to estimate Asian American candidate preferences as a racial group and by national-origin. I find strong evidence of national-origin preferences (i.e. Vietnamese for a Vietnamese candidate) among Asian American voters. In instances where the national-origin of the candidate and the national-origin of the voter did not align, voters seem to rely on partisan cues. National-origin preferences are sufficient enough that in one instance voters switched parties within the same election to vote for a candidate of the same national-origin. These findings have implications for theories of minority vote choice and challenges the existing literature on the strength of partisan cues (replication data can be found at: https://sites.google.com/view/vivienleung/research).