No abstract

Thyroid cancer bone metastases identified as part of routine clinical follow-up frequently cause significant and recurrent morbidity. The incidence of SRE and median time to first SRE in metastatic thyroid cancer to bone are similar to those reported in other solid tumors. Prospective clinical trials to assess the efficacy of antiresorptive agents in this population are needed.

Purpose of Review This review addresses our current understanding of the pathogenesis of HIV associated lipohypertrophy, and describes an evidence-based approach to treatment. Recent Findings Although the pathogenesis of HIV associated lipohypertrophy remains elusive, recent clinical and laboratory investigations in fatty acid metabolism and growth hormone dynamics have furthered our understanding of the condition. These findings have also paved the way for new therapeutic interventions, of which tesamorelin, an analogue of growth hormone-releasing hormone, has gained recognition as a promising treatment strategy against visceral fat accumulation. Recent randomized placebo-controlled trials of tesamorelin demonstrated significant reductions in visceral adipose tissue, improvement in lipid parameters, and no adverse effects on glucose tolerance. Optimal therapeutic dosing and treatment duration, though, are not yet known. Whether treatment with GHRH-analogues will translate into improved long-term metabolic and cardiovascular outcomes also remains to be seen. Summary Although the pathogenesis of HIV lipohypertrophy remains unclear, several theories and observations have led to the development of treatment strategies to counter fat accumulation and its accompanying metabolic complications. Based on clinical trials, analogues of the GH/GHRH axis appear to be most effective in reducing visceral adipose tissue.

As the number of Asian American voters has increased with each election, more research is needed to understand the participation and voting patterns of this diverse electorate. This paper offers an analysis of Asian American political participation and vote choice preferences during the 2016 presidential election. The paper begins by addressing the concerns related to Asian American political incorporation. We disaggregate Asian Americans into three voting types—voters, those who are eligible to vote but are not registered, and those who are ineligible to vote—and compare the demographic differences found across these three groups. The second half of the paper turns to Asian American candidate preferences in the 2016 election. We find that voters who report high levels of media consumption and those with a strong sense of political efficacy were more likely to support Clinton. Our analysis of non-voters suggests that the potential incorporation of these Asian Americans would result in a continued base of support for the Democratic party.

Participants with diabetes have various options for weight loss. Dietary interventions with either low-carbohydrate or low-fat diets may lead to some improvements in QOL in patients with type 2 diabetes.