Background:
Skin is the largest organ of the body and helps to regulate several physiological functions. It acts
as a barrier that protects the body against UV-radiation, toxic substances, infections, etc. The abnormal growth of the skin
cells is called skin cancer. Different types of skin cancer can be classified as Basal Cell Carcinoma (BCC) and Squamous
Cell Carcinoma (SCC); which mainly occur due to chronic exposure of UV- sunlight and pollution.
Methods:
The conventional topical treatment of skin cancer such as cream, gel, ointment, etc are more occlusive and thus
they don’t penetrate deep into the skin (dermal layer), while, it remains at the upper part of the skin (epidermal layer).
Stratum corneum act as a physiological barrier for the drug-loaded in the conventional formulation. The novel carrier
systems have the potential to facilitate the penetration of the drug deep into the skin (dermal layer) because these have less
size and higher flexibility than conventional treatment.
Conclusion:
In the present review, we have discussed various novel carrier systems being investigated for the topical
application of chemotherapeutic agents for efficient skin targeting and better dermatological as well as therapeutic benefits
with minimal systemic exposure and toxicity.
iARTICLE i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i iVishesh iSingh*, iArun iSingh iLalotra, iShelly iAgrawal, iGaurav iMishra i
Skin cancer is associated with the abnormal growth of skin cells; it most often develops on skin exposed to the sun. The conventional treatment such as cream, gel, etc. are less flexible, so they don't penetrate deep into the skin (dermal layer), it remains at the upper part of the skin (epidermal layer). Stratum corneum acts as a physiological barrier for the drug-loaded in cream and gel. An oleic acid-based vesicle is used to deliver the bioactive Resveratrol into the skin to overcome the stratum corneum. The scope of the current study is to develop Resveratrol-loaded oleic acid vesicles, which are used to enhance the permeability of drugs into the deeper layers of the skin and overcoming the stratum corneum barrier. The proposed study claims that it can retain the permeated bioactive into the deeper layer for a longer duration to get the sustained effect of the drug in the dermal region and avoid the systemic exposure and toxicity of the drug. Resveratrolloaded oleic acid vesicles would be a promising approach for the topical delivery of drugs/bioactive for the treatment of UV-Binduced precancerous skin lesions.
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