Urinary tract infections are the most important healthcare complications experienced in medicine and urology. Unfortunately, besides B-lactams, the Extended spectrum beta lactam producing Gram negative uropthogens causing UTI have become associated with resistance to other antibiotics such as aminoglycosides, fluoroquinolones etc. The use of old antibiotic such as Fosfomycin been introduced again in the field of therapeutic. The present study was conducted prospectively in the Department of Microbiology, Jodhpur, Rajasthan. Over a period of 6 months. Mid-stream morning urine samples were collected aseptically. Semi quantitative culture was done on UTI HICROME Agar. Results: In present study time 2000 (40.97%) urine sample were received, out of which 1511 (75.55%) were culture positive, 300 (15%) were sterile and 189 (9.45%) were insignificant bacterial count, Gram negative bacilli were 1100 (72.79%), Gram positive cocci were 411 (27.200%). Among GNB isolates Escherichia coli 501 (45.54%) was the most common isolate followed by Klebseilla spp.189 (17.18%), Citrobacter spp. were 130(11.81%), Pseudomonas spp.120 (10.90%), Aceinatobacter spp.110 (10%) and Proteus spp. were 50 (4.54%). Age-wise distribution 20-29 years (60.36%) group was the most common. Fosfomycin was the most sensitive antibiotic was reported. The culture and Antibiotic sensitivity testing (AST) of uropathogens should be done. Fosfomycin found to be suggesting that it could be used as empiric monotherapy for uncomplicated UTIs.
A case of Strongyloides stercoralis infection in severe protein energy malnutrition child with associated celiac disease (CD) is herein reported. The case was a 4-year-old, severely malnourished female admitted to the tertiary level hospital of Western Rajasthan, due to watery diarrhea, pain abdomen, and vomiting, not responding to treatment. The patient was HIV negative, nondiabetic, had no evidence of tuberculosis, Liver Function Test, Renal Function Test were normal was within normal limits. She had microcytic hypochromic anemia, hypoalbuminemia, and serum Antitissue transglutaminase (anti tTG IgA)was 301.35 U/ML which confirmed the diagnosis of CD. Stool parasitological examination revealed numerous rhabditiform larvae of threadworm “S. stercoralis.” After treatment with gluten free diet and Albendazole and Ivermectin, the patient recovered without evidence of S. stercoralis in follow-up stool samples.
A 32-year-old multiparous rural woman having 26 weeks of pregnancy with giant uterine fibroid extending up to the cervix had stillbirth 2 weeks back and left hospital against medical advice. She was readmitted in emergency with necrotic prolapsed uterine fibroid with offensive vaginal bleeding. On examination, the patient had necrotic prolapsed fibroid with very offensive bloody discharge and a large number of larvae of
Dermatobia hominis
(human botfly) were crawling in necrotic tissue. The location of this infestation at genital region is an extremely rare occurrence in postdelivery patients.
Biofilm are groups of microorganism encased in a matrix of extracellular polysaccharide (slime), called polysaccharide intercellular adhesion (PIA). Bacteria commonly involved include , , , and . The present study was performed to identify antibiotic resistance pattern & their ability to form biofilm in gram negative clinical isolates. All clinical samples received in laboratory for microbial culture during study period of 12 months (2017 to 2018) were included in this study Antibiotic susceptibility testing, ESBL & MBL detection was done for clinical isolates. Biofilm productions were determined by Congo red agar method, Christenson’s Test Tube method and Tissue culture plate method. 327 gram negative isolates were detected. Maximum were (32.72%) followed by (28.44%), (16.51%), (16.51%), Citrobacter species (3.97%). Maximum isolates showed resistance to ampicillin (93.27%) followed by amoxiclave (87.46%), ceftazidime (74%). Out of 327 GNB isolates, biofilm produced by 64 (19.57%) isolates by Tissue culture plate (TCP) method, 38(11.62%) by Congo red agar (CRA) methods and 23 (7.03%) by Tube methods. Maximum biofilm were detected in (24.29%). There is increase prevalence of multidrug resistant& biofilm forming bacteria. The routine monitoring of multidrug resistance pattern & biofilm detection can be recommended in clinical laboratories to guide proper antibiotic treatment.
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