Objetivo: Revisar na literatura os aspectos atuais sobre a utilização da Phyllanthus niruri (quebra-pedra) no tratamento da litíase renal. Métodos: Trata-se de uma revisão integrativa, realizada por meio de levantamento bibliográfico de publicações que investigaram o uso da Phyllanthus niruri no tratamento da litíase renal, indexadas às bases de dados Pubmed, Scielo e Lilacs. Foram incluídos artigos originais, com desenho transversal, caso-controle e coorte, bem como, artigos de revisão, em inglês, português e espanhol, sem limites de ano de publicação. Resultados: Do total de 52 artigos, 17,3% (n=9) foram incluídos para leitura integral e discussão. Os resultados disponíveis permitiram verificar os benefícios do uso da P. niruri no controle da urolitíase, suas ações antiespasmódicas e anti-hiperalgésicas, e seus compostos fitoquímicos envolvidos em sua ação terapêutica. Em relação a toxicidade, esta não foi observada com uso de chás e extratos, embora seja contraindicada na gestação. Sua atividade farmacológica foi positiva, assim como seu resultado clínico e mercadológico. Final considerations: Conclui-se, portanto, que a “quebra-pedra” possui potencial clínico para abordagem terapêutica da litíase renal em humanos.
Considering the vast use of sweeteners by the Brazilian population and the constant need for toxicological studies of food additives, this study aimed to evaluate the cytotoxic and mutagenic potentials of the sodium saccharin and/or sodium cyclamate sweeteners in plant (Allium cepa) and animal (Mus musculus) test systems based on concentrations permitted by the Brazilian laws. In A. cepa, both the sweeteners individually and their combinations concentration and exposure time (ET: 48, 72 and 168 h) dependently exerted cytotoxic and mutagenic effects. Similarly, an increased in micronuclei formation was also observed by the sweeteners in peripheral blood cells in mice. More toxic effects were observed with the combination doses at 168 ET. There may be a synergistic effect and DNA damage with an increasing concentration and ET. In conclusion, the concentrations considered safe by the Brazilian laws had significant cytotoxic and mutagenic activity on the eukaryotic cells.
This study aimed to evaluate the physical-chemical composition and hypoglycemic properties of okra and eggplant flours. Initially, the vegetables were dehydrated, crushed to the point of flour, conditioned and stored until use. The flours were subjected to physical-chemical evaluation to determine the moisture, lipids, proteins, carbohydrates and polyphenols contents and, then, the experimental analysis was carried out. This was done using Swiss mice, distributed in 6 groups (n = 3), one healthy, two diabetic controls and three diabetics treated with commercial diets containing eggplant flour, okra and the mixture of the two flours. The survey lasted 20 days, with daily measurement of water and food and, in the interval of 5 days, blood glucose and weight. The research was approved by the Animal Experimentation Ethics Committee of the same institution, under protocol number 157/16. Statistical analysis was performed using STATISTICA Software version 7.0. The results showed that the flours have an important nutritional composition, mainly in terms of fiber content. In relation to functional activity, okra flour was able to significantly reduce the glycemia of mice when compared to eggplant flour, a result comparable to that of other authors, who emphasize the importance of fibers and bioactive compounds in obtaining this result. both flours had a good nutritional composition, but the okra was more efficient in reducing the glycemia of diabetic mice, and may become an alternative in the dietary treatment of this pathology.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.