This case series demonstrates that classical homeopathy may have a solution to psoriasis and its complications which goes beyond skin clearance and achieves general well‐being. The variety in clinical phenotypes and their response to treatment may be explained on the basis of the theory of “Levels of Health."

This a preprint and has not been peer reviewed. Data may be preliminary.

Fever is the hallmark of efficient acute inflammatory response, which may be disrupted in chronic inflammatory conditions. “The Continuum Theory” proposes that the return of acute inflammatory states with high fever herald improvement in chronic diseases during treatment. Our objective was to investigate if a correlation exists between chronic inflammation and efficient acute inflammation. In a case control study, the reports of patients diagnosed with chronic inflammatory conditions with at least 6 months of follow up under homeopathic treatment were retrospectively sampled from homeopathic medical practitioners from Greece, India, Romania, and Russia. 20 patients who improved under homeopathic treatment and 20 age matched controls of those who did not improve were selected. The occurrence of common acute infectious diseases with fever during the follow up period was investigated. The Odds Ratio of improving with respect to development of acute infectious diseases was calculated and graphs were plotted to study the pattern in each case. The average age of the cases and controls was 28.4 and 27.9 years respectively. 18/20 cases and 4/20 controls developed common infectious diseases with fever respectively. Odds Ratio of improving with respect to development of acute infectious diseases was 36 (95%, CI: 5.7973 to 223.5513), z statistic: 3.846 (p = 0.0001). In this case control study, appearance of common acute infectious diseases with fever was strongly associated with improvement in the chronic inflammatory conditions.

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Background: Prior to any revascularization procedure for coronary artery disease, it is essential to identify viable myocardium which will likely benefit from it. In such a situation, delayed enhanced cardiac MRI is beneficial.Methods: Our study consisted of 50 patients with at least a one-month prior history of myocardial infarction (MI), abnormal findings on electrocardiography (ECG), and 2D-echocardiography (2D-ECHO), who were subjected to cardiac MRI performed on a 3T MRI machine. The MRI scans were evaluated for anatomical and especially functional characteristics of the heart, such as wall motion. On late gadolinium enhancement (LGE), the diseased segments were classified into two categories: < 50% LGE (viable) and > 50% LGE (nonviable).Results: Of the 378 diseased segments detected on LGE, 137 (36.2%) segments showed < 50% LGE and 241 (63.8%) segments showed > 50% LGE. The segments showing < 50% LGE showed normokinesia or hypokinesia, with none of the segments showing akinesia or dyskinesia, whereas the segments showing > 50% LGE showed akinesia or dyskinesia predominantly. This was found to be statistically highly significant (p-value < 0.001).Conclusion: Delayed enhanced-cardiac magnetic resonance (DE-CMR) imaging in patients with ischemic heart disease (IHD) helps evaluate the severity of the infarcted myocardium by classifying the diseased myocardium into viable and non-viable, as viable myocardium is more likely to regain functional recovery than non-viable myocardium. It also predicts the functional recovery of the myocardium after revascularization therapy.

Objective Suppression of efficient acute inflammation may be one of the mechanisms behind the onset of chronic low-grade inflammation. Efficient acute inflammatory response to pathogenic stimulus may not be possible in the presence of chronic inflammation. We investigated if a correlation exists between chronic and efficient acute inflammation. Methods Design Case control study. Setting Homeopathic medical practices in 4 countries Patients with definite improvement in chronic inflammatory conditions with at least 6 months of follow up were selected as cases. Age matched controls involved those who did not improve. Event of interest Occurrence of common acute infectious diseases with fever during the follow up period. Statistical analysis Odds Ratio of improvement in the chronic condition, with development of acute infectious diseases with fever was calculated. Graphs were plotted to study this correlation in individual cases. Results 20 cases and 20 age matched controls were selected. Average age was 28.4 and 27.9 years respectively. 18/20 cases and 4/20 controls developed common infectious diseases with fever during the follow up period. Odds Ratio of the chronic condition improving, with development of acute infectious diseases with fever was 36 (95 %, CI: 5.7973 to 223.5513), z statistic: 3.846 and significance level was p = 0.0001. Graphs of individual cases showed distinct patterns confirming the same. Conclusions In this case control study, appearance of common acute infectious diseases with fever during treatment was strongly associated with improvement in the chronic inflammatory conditions. Larger studies are needed to further establish the correlation. Supported by Nil

Systemic lupus erythematosus (SLE) is known for marked heterogeneity of clinical manifestations and pathogenesis with the potential of affecting virtually every organ system. Neuropsychiatric manifestations of systemic lupus erythematosus are difficult to recognize and treat as they remain one of the least understood complications of this disease. Our case describes a 42-year-old female who presented to the emergency department with proximal weakness of the left lower extremity, magnetic resonance imaging (MRI) of the brain revealed a small infarct in the medial left temporal lobe. Workup was remarkable for elevated inflammatory markers. The patient was discharged on appropriate medical therapy however returned to the emergency department one month later after a witnessed focal seizure. Neuroimaging was consistent with cerebral vasculitis and autoimmune workup revealed a diagnosis of SLE. Our case highlights the importance of recognizing that neuropsychiatric manifestations of SLE often occur in absence of other systemic manifestations and can be the initial presentation of SLE. Maintaining a high clinical suspicion for Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) could afford the ability to halt disease progression in the earliest of phases and thus improve quality of life through early administration of appropriate pharmacotherapy.

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