Correlation Between Acute and Chronic Inflammatory States, a Case Control Study

Abstract

Fever is the hallmark of efficient acute inflammatory response, which may be disrupted in chronic inflammatory conditions. “The Continuum Theory” proposes that the return of acute inflammatory states with high fever herald improvement in chronic diseases during treatment. Our objective was to investigate if a correlation exists between chronic inflammation and efficient acute inflammation. In a case control study, the reports of patients diagnosed with chronic inflammatory conditions with at least 6 months of follow up under homeopathic treatment were retrospectively sampled from homeopathic medical practitioners from Greece, India, Romania, and Russia. 20 patients who improved under homeopathic treatment and 20 age matched controls of those who did not improve were selected. The occurrence of common acute infectious diseases with fever during the follow up period was investigated. The Odds Ratio of improving with respect to development of acute infectious diseases was calculated and graphs were plotted to study the pattern in each case. The average age of the cases and controls was 28.4 and 27.9 years respectively. 18/20 cases and 4/20 controls developed common infectious diseases with fever respectively. Odds Ratio of improving with respect to development of acute infectious diseases was 36 (95%, CI: 5.7973 to 223.5513), z statistic: 3.846 (p = 0.0001). In this case control study, appearance of common acute infectious diseases with fever was strongly associated with improvement in the chronic inflammatory conditions.

Correlation between acute and chronic inflammatory states, a case control study

“…The Table 1 provides the characteristics of participants, both cases and controls. The detailed data of individual cases is available at the data repository (19) The average age of the cases and controls were 28.4 and 27.9 years respectively. Among cases improving under homeopathic treatment, 18/20 patients had common infectious diseases with fever during the follow up period, while 4/20 patients among the controls developed common infectious diseases with fever (Fig.…”

A Case of Infective Endocarditis Treated With Homeopathy Medicine

“…The Levels of Health Theory was developed by the author of this paper (Prof. George Vithoulkas), whose clinical observations were proven by many other physicians-homeopaths, [13][14][15][16][17] who have shown that patients suffering from severe degenerative pathology rarely develop ordinary acute diseases with high fever. According to the Levels of Health Theory, there are 4 groups and 12 levels of health (LH).…”