BACKGROUNDLiver plays a major role in maintaining the haematological parameters in normal and maintain the haemostasis. Liver is the storage site for iron, B12 and folic acid, which are necessary for the normal haematopoiesis. Liver also secretes the clotting factors and the inhibitors and keep the haemostasis in equilibrium. Hepatocellular failure, portal hypertension and jaundice may affect the blood picture. Chronic liver disease is usually accompanied by hypersplenism. Diminished erythrocyte survival is frequent. In addition, both parenchymal hepatic disease and cholestatic jaundice may produce blood coagulation defects. Dietary deficiencies, alcoholism, bleeding and difficulties in hepatic synthesis of proteins used in blood formation or coagulation add to complexity of the problem.
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