Introduction: Acute mesenteric ischemia (AMI) is the sudden onset of small intestinal hypoperfusion, which can be due to reduction or cessation of arterial inflow. It can be embolic or thrombotic. AMI is a potentially fatal vascular emergency, with overall mortality of 60%–80%. The present study was designed to study presentation, risk factors, and various outcomes of AMI patients, who were treated in the tertiary hospital. Methodology: All patients with features suggestive of AMI were taken in study. All patients underwent explorative laparotomy with exteriorization of bowel after initial resuscitation. Postoperatively, refeeding enteroclysis was done. Observation and Results: The total mortality rate was 62.50%. In patients with functional bowel length of 1 foot, 90.90% patients died. In patients with functional bowel length of 5–6 feet, only 12.50% died. It was observed that the mortality rate was more in the age group of 50–59 years with functional bowel length of 1 foot or <1 foot. Refeeding enteroclysis is an effective technique to use distal bowel. Contrast-enhanced computed tomography of the abdomen more suggestive of this pathology. Conclusions: A strong clinical suspicion and an aggressive approach should be considered in dealing with this condition because the outcome mainly depends on rapid diagnosis and treatment. With understanding of the pathogenesis of AMI and the better utilization of available radiological investigations, an improved outcome can be achieved. Mortality rates with refeeding enteroclysis are comparable with that of bowel anastomosis. This condition needs future research.
BACKGROUND AND OBJECTIVE: Breasts are an important aspect of a woman's femininity and all aberrations in their functional and cosmetic attributes are essential for scientic evaluation as breast cancer has become the most common cancer among women worldwide. Its risk increases with age and menopausal status. Serum parameters like Ferritin and TIBC concentration is altered in sera of these patients. Iron homeostasis is inuenced by estrogen and overload impacts cellular proliferation and physiological dysfunction in electron and oxygen transport, energy production and DNA synthesis. A vicious cycle between breast cancer, iron homeostasis deregulation, menopausal status and serum parameters derangement enables us to prognosticate such patients. METHOD: Histopathologically conrmed, 50 newly diagnosed cases were analyzed with age matched 50 clinically healthy controls with no family history. Level of serum ferritin was estimated by Sandwich Elisa using Ferritin SAElisa kit and serum TIBC level measured with CL-1000i Chemiluminescence immunoassay analyzer. RESULT: Serum ferritin level in breast cancer cases (300.73±25.33ng/ml) was statistically higher than in controls (85.22±41.80ng/ml). In breast cancer, ferritin level was higher in postmenopausal (300.73±25.33ng/ml) compared to premenopausal (228.059±11.24ng/ml) patients and even in their healthy counterparts.Serum TIBC level in breast cancer (772.99±127.93) was higher than in controls (329.41± 69.40).In postmenopausal breast cancer female TIBC level was higher (815.39±104.32) compared to premenopausal females (652.31±110.86) and similarly it was higher in postmenopausal healthy controls than in premenopausal controls and signicant statistically. CONCLUSION: Serum ferritin and TIBC parameters can be used as prognostic markers for breast cancer and their levels are elevated in postmenopausal females of both breast cancer patients and healthy cases.
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