Matrix tablets using PEC as matrix and Diltiazem HCl as a model drug were formulated by wet granulation technique. The matrix tablets were evaluated for physical properties, in vitro release and release data analysis The maximal yield was obtained when the ratio of guar gum: pectin was 3:7 (w/w).Release kinetic was evaluated by using USP XXIV dissolution apparatus type II was 89.54 %. It was concluded from the study that guar-pectin binary polymeric matrix system is an interesting alternative for preparing sustained release tablets.
Mucoadhesive microspheres of Ziprasidone HCL were prepared using sodium alginate as a shell forming polymer and HPMC-E5 as a mucoadhesive polymer for the potential use of treating schizophrenia. These were achieved by injection molding technique (Ionic cross linking). The microspheres exhibited good mucoadhesive properties and drug release from mucoadhesive microspheres was slow and extended over a longer period of time, depending on the composition of sodium alginate coat. The present investigation is aimed to prepare the sustained release mucoadhesive microspheres of Ziprasidone HCL using polymers like HPMC-E5 and sodium alginate. The drug to polymers ratio (Ziprasidone HCL, HPMC-E5 and sodium alginate) in optimized batch M 1 was kept at 1: 1: 3. The prepared beads were characterized for its particle size distribution, percent drug content, mean diameter and crushing strength, surface morphology (SEM), in vitro wash off test and in vitro drug release. The prepared beads were found to be optimal in terms of particle size and entrapment efficacy. There were no compatibility issues and the crystallinity of drug was found to be reduced in prepared microspheres, which were confirmed by DSC and PXRD studies. The time to release 90% of drug in the optimized batch M1 was 10 hr. Further investigations are required to reduce the amount of polymer in microspheres that can provide maximum drug loading and acceptable dosage form.
In the present study, alginate based microspheres of Olanzepine was prepared by ionotropic external gelation technique utilizing calcium chloride as a cross linking agent to enhance bioavailability and residence time. The prepared microspheres are discrete, spherical and free flowing which was characterized by entrapment efficiency, particle size, in-vitro release behavior, scanning electron microscopy, in-vivo study etc; Optimized formulation was followed zero-order release kinetic. In-vivo evaluation of antidepressant activity of Olanzapine formulation showed that duration of immobility time was significantly decreased as compare to control and standard marked SR formulation. The optimized formulation was mucoadhesive in nature. Stability studies was carried out for F9 at a temperature of 40±2°C/ RH 75±5% formulation revealed that the drug behavior was within permissible limits.
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