In the present study, alginate based microspheres of Olanzepine was prepared by ionotropic external gelation technique utilizing calcium chloride as a cross linking agent to enhance bioavailability and residence time. The prepared microspheres are discrete, spherical and free flowing which was characterized by entrapment efficiency, particle size, in-vitro release behavior, scanning electron microscopy, in-vivo study etc; Optimized formulation was followed zero-order release kinetic. In-vivo evaluation of antidepressant activity of Olanzapine formulation showed that duration of immobility time was significantly decreased as compare to control and standard marked SR formulation. The optimized formulation was mucoadhesive in nature. Stability studies was carried out for F9 at a temperature of 40±2°C/ RH 75±5% formulation revealed that the drug behavior was within permissible limits.
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