N ebivolol hydrochloride is unique antihypertensive drug, which gets completely absorbed upon oral administration, with t max 1.5-4 h. The poor aqueous solubility leads to slow rate of absorption. An attempt has been made to enhance dissolution of nebivolol (NB) using solid dispersion (SD) and SD adsorbate (SDA) techniques. Various hydrophilic excipients such as polyethylene glycol 6000 (PEG), gelucire 50/13 (GL), and neusilin US2 (NUS) at different ratios were used. The prepared SDA of NB was characterized for % drug yield and other physical characteristics and in vitro drug dissolution studies in 0.1N HCl (pH 1.2). The formulation optimized on the basis of in vitro drug dissolution and % drug content was also characterized by the Fourier transform infrared (FTIR) spectroscopy; differential scanning calorimetry (DSC), X-ray powder diffractometry analysis (XRD). The FTIR study indicated no interaction between the drug and polymer. DSC thermograms showed the significant change in melting peak of the NB when prepared as SDA suggesting the change in crystallinity of NB. The data from the XRD showed that the drug was still detectable in its solid state in the SDA of PEG and disappeared in case of higher ratio of GL. An increased dissolution rate of NB at pH 1.2 was observed when the drug was dispersed in these carriers in the form of physical mixtures (PMs), SDs by solvent evaporation methods (SMs), SDs by fusion method and SDAs by fusion method. NB released faster from the SDAs than from the pure crystalline drug, the PMs, the SMs, or the SDs. Thus, this study was proved as a promising approach for the improvement of dissolution rate and solubility of NB.

Present investigation deals with the utilization of Bagasse fly ash (BFA) a sugar industry waste and Zeolitic material (MZBFA), synthesized from BFA by combined conventional and microwave reflux method as adsorbents for the extraction of Acephate (ACP), an organophosphorus pesticide from aqueous solution. The synthesized adsorbents were characterized using various techniques such as FTIR, PXRD and SEM. The effect of various experimental parameters has been investigated using a batch adsorption technique for the extraction of ACP. The extent of removal is increased with decrease in initial ACP concentration and particle size of the adsorbent. Adsorption was fast and the equilibrium was established within 90 min. Pseudo-first-order, Pseudo-second-order, Bangham and intra-particle particle diffusion models were used to fit the experimental data. Pseudo-second-order rate equation was able to provide realistic description of adsorption kinetics. Equilibrium isotherms were analyzed by Freundlich, Langmuir, Dubinin-Radushkevich and Tempkin isotherm equations. Langmuir equation was found to best represent the equilibrium data. The thermodynamic study showed that adsorption of ACP on MZBFA is higher than that on BFA. The results indicate that such Zeolitic material could be employed as low cost alternatives to Bagasse fly ash in wastewater treatment for the removal of pesticides