A series of methylpiperidinyl phenols, methylphenylmorpholinyl phenols and methylthiophenylmorpholinyl phenols were synthesized in one-pot transformation by Mannich reactions using infrared irradiation under solvent-free conditions. The chemical structures of the compounds were proved by IR, 1 H NMR, 13 C NMR and MS spectroscopic data.
Antihypertensive activity X 0120Synthesis and Antihypertensive Effects of New Methylthiomorpholinphenol Derivatives. -The novel compounds (I) are evaluated for their antihypertensive activity. The results are discussed in detail in comparison with other cardiovascular drugs such as captopril, losartan and omapatrilat. LQM303 (Ic) exhibits the best decreasing effect in both systolic and diastolic pressure and the best heart rate decreasing effect. -(VELAZQUEZ, A. M.; MARTINEZ, L.; ABREGO, V.; BALBOA, M. A.; TORRES, L. A.; CAMACHO, B.; DIAZ-BARRIGA, S.; ROMERO, A.; LOPEZ--CASTANARES, R.; ANGELES*, E.; Eur.
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