This study reports in vitro anticholinesterase, antioxidant and antimicrobial effects of the n-hexane, dichloromethane, ethanol and ethanol-water extracts prepared from Pistacia terebinthus L. fruits and Pistacia khinjuk Stocks seeds as well as their total phenolic and flavonoid contents, and fatty acid compositions. Ethanol and ethanol-water extracts of both species exhibited higher anticholinesterase activity than galanthamine. Among ABTS, DPPH and CUPRAC assays, the highest antioxidant capacity of the extracts was found in the last one. P. terebinthus ethanol extract being rich in flavonoid content showed the best cupric reducing effect. All extracts possessed no antimicrobial activity. The main fatty acid in P. terebinthus fruits (52.52%) and P. khinjuk seeds (59.44%) was found to be oleic acid. Our results indicate that P. terebinthus fruits and P. khinjuk seeds could be a good source of anticholinesterase compounds, and could be phytochemically investigated.
The genus Nepeta (Lamiaceae) and Achillea (Asteraceae) are widely distributed in Turkey.In this study, the essential oils of Nepeta italica L. and Achillea filipendulina LAM. collected from Dicle district in Diyarbakir province in the Southeast Anatolia and from Hakkari province in East Anatolia of Turkey, were obtained by hydrodistillation of the aerial parts. The essential oils from Nepeta italica and Achillea filipendulina obtained by hydrodistillation were analyzed by gas chromatography-mass spectrometry GC Clarus 600-MS Clarus 600 C (Perkin Elmer) and microelements were analyzed by Perkin Elmer Optima 2100 DV ICP OEMS, and also antioxidant activity analyzed by DPPH radical scavenging assay. Achillea filipendulina and Nepeta italica essential oils showed similar antioxidant activity with inhibition of 55.3 % and 51.3 %, respectively, which are higher than BHT synthetic antioxidant with 23 % inhibition.
Alkylaminophenols are synthetic derivatives well known for their anticancer activity. In this work, we report the antimicrobial and antioxidant activity of such compounds. A series (4,5,6) of alkylaminophenol compounds were prepared with fairly good yields by Petasis reaction. Synthesized compounds were characterized by 1 H-NMR and 13 C-NMR. The obtained compounds were tested against Gram-positive and Gram-negative bacteria. The compound 4 showed antimicrobial activity at a concentration of 10 mg/mL, while the 6 compound showed activity on S. aureus. Phenolic compounds have attracted attention due to their proximal and antioxidant activities. Since alkylaminophenols have phenolic structure, their antioxidant activity has been investigated. Thus, drug-active substances with high antioxidant capacity against diabetes, heart disease, and cancer were synthesized.
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