Yeni p-alkilaminofenol Bileşiklerinin Sentezi ve Antimikrobiyal ve Antioksidan Aktivitelerinin Araştırılması

Abstract

Alkylaminophenols are synthetic derivatives well known for their anticancer activity. In this work, we report the antimicrobial and antioxidant activity of such compounds. A series (4,5,6) of alkylaminophenol compounds were prepared with fairly good yields by Petasis reaction. Synthesized compounds were characterized by 1 H-NMR and 13 C-NMR. The obtained compounds were tested against Gram-positive and Gram-negative bacteria. The compound 4 showed antimicrobial activity at a concentration of 10 mg/mL, while the 6 compound showed activity on S. aureus. Phenolic compounds have attracted attention due to their proximal and antioxidant activities. Since alkylaminophenols have phenolic structure, their antioxidant activity has been investigated. Thus, drug-active substances with high antioxidant capacity against diabetes, heart disease, and cancer were synthesized.

Synthesis, spectral characterization, DFT, and molecular docking studies of 2 - ((2,3-Dihydrobenzo [b] [1,4] dioxin-6-yl) (1H-indol-1-yl) methyl) phenol compound

“…The compounds having antioxidant activity enables them to be used in chemotherapy. 5,6 Although there are compounds synthesized in this field in recent years, the diversity of cancer types also accelerates the synthesis of new bioactive compounds. In addition, the fact that the radicals formed as a result of cancer cells become neutral and have antioxidant properties increase the importance of this compound class.…”

“…Synthesis was carried out according to the procedure in the literatüre (Figure1). 5 The chemicals used for synthesis were used directly without any extra purification. Structure analysis of the synthesized compound has been made by Bruker FT-IR spectrometer and Agilent 600 MHz NMR spectrometers.…”

Natural bond orbital (NBO) population analysis and non-linear optical (NLO) properties of 2-(azepan-1-yl(naphthalen-1-yl)methyl)phenol

“…Alkylaminophenol compounds form a class of heterocyclic compounds used in various fields from pharmacology to polymer chemistry. [1][2][3][4][5][6] Generally, they are used as drug active material. Also, the phenolic groups have enabled them to have antioxidant activities too.…”

2- (azepan-1-il (naftalen-1-il) metil)fenol Bileşiğinin Sentezi ve Kuantum Kimyasal Hesaplamaları

“…Kanser türlerinin çeşitliliği, tedavide kullanılacak yeni ilaçların varlığına ihtiyaç duymaktadır. Genellikle kemik kanserinin tedavisinde kullanılan alkilaminofenoller, Petasis reaksiyonu (Boronik Mannich Reaksiyonu) ile sentezlenir (Beisel & Manolikakes, 2015;Candeias, Montalbano, Cal, & Gois, 2010;Chouguiat, Boulcina, Carboni, Demonceau, & Debache, 2014;Hosseinzadeh, Lasemi, Oloub, & Pooryousef, 2017;Klopfenstein vd., 2000;Neogi, Roy, & Naskar, 2010;Prasad Reddy, Govardhana Reddy, Kumar, Reddy, & Shankar, 2016;Shi vd., 2012;Tremblay-Morin, Raeppel, & Gaudette, 2004;Ulaş, 2019;Ulaş, Özkan, & Tolan, 2019;Wang, Li, Shen, & Song, 2014;Wu, Givskov, & Nielsen, 2019;Yu, Wu, Cheng, Wei, & Li, 2009). İlk kez 1993 yılında bir antifungal ajan olan naftifinin sentezi için Nicos Petasis tarafından pratik bir yöntem olarak kullanılmıştır (Petasis & Akritopoulou, 1993).…”