Blastocystis spp pathogenic potential remains controversial. Recently, many researchers have suggested the possible etiological relationship between symptomatic skin rashes and Blastocystic morphological forms, genetic diversity and microbiota interaction. A small observation series of acute and chronic urticaria caused by Blastocystic hominis in elderly patients has been herein presented. These cases emphasize the importance of adequate parasite verification under appropriate clinical settings and upon elimination of other more common causative factors as well as the significance of proper etiological treatment in urticaria patients.
Rowell syndrome is a rare skin disease described as an association of erythema multiforme and systemic lupus erythematosus, immunologically characterized by speckled antinuclear, anti-Ro, and anti-La antibodies. The majority of described cases affect middle-aged women. We report a case of a 53-year-old man with no previous history of lupus erythematosus, who developed erythema multiforme-like lesions and immunological findings consistent with Rowell syndome upon an intake of non-steroidal anti-inflammatory drugs. The patient responded well to systemic steroids and hydroxychloroquine. A short overview, emphasizing the specific clinical, laboratory and histology findings of this peculiar syndrome, is also presented.
Herein, an otherwise healthy 63-year-old Caucasian woman with a three month-history of progressive symmetrical swelling and of the fingers, lumbal and abdominal pain, proximal muscle weakness, and heliotropic rash resembling V- neck, histologically verified as multicentric reticulohistiocytosis (MRH), is presented. Multiple computer tomography scans failed to detect ovarian cancer despite elevated Ca 125, however, it was verified six months later by magnetic resonance investigation. Multicentric reticulohistocytosis (MRH) is a rare systematic disease that targets skin, mucoses and synovium, resulting in skin nodules, mucosal lesions and deforming painful mutilating polyarthritis. Twenty – five percent of all patients are associated with internal malignancies, hence, MRH paraneoplastic nature remains extremely controversial. Our case showed a peculiar dermatomyositis-like clinical subtype, which we consider suggestive for verification of an underlying malignancy.
An otherwise healthy 63-year-old woman presented with a 3-month history of weight loss, malaise, and abdominal pain as first symptoms, followed by back pain, proximal muscle weakness, and symmetrical painful decapacitating arthritis of the small joints of the hands. On physical examination, reddish-brown papules and nodules were found on the dorsum of the fingers, some overlying the periungual area (Fig 1). A photo-distributed pink, violaceous erythema with telangiectasias was noticeable on the neck and anterior chest (Fig 2). Ovarian cancer was found during the follow-up period. Punch biopsy of a nodule was performed (Figs 3 and 4).
COVID-19 is an ongoing multisystemic viral infection, which affects both adults and children. The virus has a complicated and not fully understood pathophysiological mechanism of damaging different organs and systems, including the skin. Cutaneous manifestations classification is complicated by the great variety of lesions and histological appearances, neither specific. Herein, a thorough overview of the clinical and pathological peculiarities of skin changes observed in the acute and re-convalescent stages of COVID-19 infection, is highlighted. The pathophysiological mechanisms, suggested to trigger and sustain the dermatological dysfunction, are also considered in the vicinity of authors’ personal experience.
Interstitial granulomatous dermatitis is a rare skin condition that presents with erythematous violaceous plaques mostly associated with pruritus and pain. The etiopathogenesis remains obscure, hence, it is often associated with autoimmune systemic diseases and systemic infections. Herein, we present an anecdotal case of interstitial granulomatous dermatitis in a male patient with immune constellation of systemic lupus erythematosus. A comprehensive review of the literature on the possible pathogenetic pathways and clinical peculiarities is also highlighted.
Nowadays, dermal fillers are used in aesthetic medicine very often, hence, a large number of complications after hyaluronic acid products application may occur. Upon early diagnosis and adequate treatment, almost any adverse reaction can be avoided. Proper injection technique, approved products and detailed anatomical education decrease the risk of long-term sequelae. Herein, a clinical case of foreign body granuloma formation in the area of nasolabial fold after injection of hyaluronic filler is described. A short overview of the pharmacodynamics and possible side effects of the injectable hyaluronic fillers is also presented.
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