A a result of an investigation of the effects of drugs on the carbohydrate metabolism of rats, control glucose tolerance tests revealed that pedigreed, sexually mature, male rats of the Yale strain 2 exhibited a significantly lower glucose tolerance than rats of the Wistar strain of corresponding age and sex, grown under the same conditions and maintained on the same diet. In view of the extensive use of rats in carbohydrate studies, considerable importance is attached to the questions, a), Which strain has a 'normal' carbohydrate tolerance? b), What criteria justify the designation 'normal' carbohydrate tolerance in the rat?Relative to these questions, the data here reported cover a period of 22 months and consist of 425 glucose tolerance tests on 240 rats, normal with respect to weight gains and general physical appearance.
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