INHERITANCE OF GLUCOSE TOLERANCE<sup>1</sup>

Cole, Versa V.; Harned, Ben K.; Keeler, Clyde E.

doi:10.1210/endo-28-1-25

Cited by 8 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data were not sufficient to define the number of loci involved. Cole and Harned (31) and Cole et al (32) evaluated glucose tolerance in two inbred strains of rats and concluded that the phenotypic differences observed were probably the result of "one principle gene plus modifiers, the principle gene tending to be incompletely recessive." Charlesworth (20) convincingly demonstrated small but significant differences in blood glucose between five strains of mice.…”

Section: Discussionmentioning

confidence: 99%

Genetic Analysis of Glucose Tolerance in Inbred Mouse Strains: Evidence for Polygenic Control

Kaku

Fiedorek²,

Province³

et al. 1988

Diabetes

View full text Add to dashboard Cite

To determine genetic factors involved in diabetes susceptibility in inbred strains of mice, we initially evaluated differences in fed plasma glucose and insulin concentrations among six strains (AKR/J, C3H/HeJ, C57BL/6J, C57L/J, DBA/2J, and SWR/J). There was considerable variation in fed plasma glucose concentration, with C3H/HeJ mice the most glucose tolerant (174 +/- 7 mg/dl) and C57BL/6J mice the least glucose tolerant (252 +/- 7 mg/dl, P less than .0001 vs. C3H/HeJ mice). Glycosylated hemoglobin of C57BL/6J mice (4.0 +/- 0.06%) was also higher than that of C3H/HeJ mice (3.52 +/- 0.06%, P less than .0001). The fed plasma insulin concentration did not differ between these two strains. Glucose tolerance was further evaluated in overnight-fasted C3H/HeJ and C57BL/6J mice by an intraperitoneal glucose tolerance test (IPGTT). Although fasting plasma glucose did not differ, the most remarkable difference in plasma glucose during IPGTT between C57BL/6J and C3H/HeJ mice was noted at 30 min (489 +/- 29 vs. 227 +/- 20 mg/dl, P less than .001). To determine the number of genes involved in the phenotypic difference in glucose tolerance, C57BL/6J males were crossed with C3H/HeJ females (F1, C3H/HeJ X C57BL/6J), and the F1 hybrid females were backcrossed with C57BL/6J males (backcrossed, F1 X C57BL/6J). Plasma glucose after 30 min on IPGTT was 219 +/- 8 (n = 21), 456 +/- 18 (n = 23), and 292 +/- 13 (n = 23) mg/dl for C3H/HeJ, C57BL/6J, and F1 mice, respectively (P less than .001 for all comparisons).(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic Analysis of Glucose Tolerance in Inbred Mouse Strains: Evidence for Polygenic Control

Kaku

Fiedorek²,

Province³

et al. 1988

Diabetes

View full text Add to dashboard Cite

show abstract

“…The influence of various single genes and combinations of genes in the rat has been indicated by numerous studies. Strain variations in anatomical and physiological characteristics of laboratory rats have been noted by many observers, particularly as to basal metabolic level (18), glucose tolerance (5), endocrine glands (10,15), body weight (11), and audiogenic seizures (6). All of these cited studies support the modern concept of the role of the genes in ordering and directing complex metabolic physiology.…”

Section: Historymentioning

confidence: 80%

The influence of the genotype on the retention of a maze habit in the rat following electroshock convulsions.

Bendig

Braun²

1951

Journal of Comparative and Physiological Psychology

View full text Add to dashboard Cite

“…A series of studies by Cole et al describe two strains of rats differing in glucose tolerance which show striking similarities to HG and LG line mice such as nearly parallel glucose tolerance test curves differing by about 30 mg% at each point, and a more rapid growth rate in the strain with higher glucose levels [18]. The authors concluded that decreased glucose tolerance is probably the result of one principal gene plus modifiers with the principal gene tending to be incompletely recessive [19].…”

Section: Glucose Tolerance Testmentioning

confidence: 99%

Genetic selection for high and low fasting blood glucose levels in mice. I. Fasting blood glucose levels, glucose tolerance and isolated tissue studies

1973

View full text Add to dashboard Cite

Swiss-Hauschka mice have been selected for high (HG) and low (LG) fasting blood glucose (FBG) levels for four generations. All rantings were brother to sister. Differences in mean FBG levels have remained relatively constant (20 to 30 rag~ between the two lines since initiation of selection (p < 0.001). Body weights have declined more rapidly with inbreeding in the LG line as compared to the HG line through Fs, but no further decline was noted in the Fa generation. Fasting serum immunoreactivo insulin (It~I) levels were variable and mean levels for the two lines did not differ significantly. A comparison of glucose tolerance data between F 3 }IG and LG line animals showed generally higher mean glucose levels in the HG line in both fasted and randomfed states. The mean delta glucose levels during the test, however, were nearly identical in both lines. A dietary influence on glucose tolerance was shown. Several in vitro tissue studies revealed no signi~cant differences in hepatic glycogen and pancreatic insulin content between HG and LG line animals. Isolated tissue sensitivity to insulin appeared indistinguishable between the lines; however, hepatic gluconeogenesis and retinal glucose-6-1~C oxidation rates in ttG line mice may be enhanced.

show abstract

INHERITANCE OF GLUCOSE TOLERANCE¹

Cited by 8 publications

References 0 publications

Genetic Analysis of Glucose Tolerance in Inbred Mouse Strains: Evidence for Polygenic Control

Genetic Analysis of Glucose Tolerance in Inbred Mouse Strains: Evidence for Polygenic Control

The influence of the genotype on the retention of a maze habit in the rat following electroshock convulsions.

Genetic selection for high and low fasting blood glucose levels in mice. I. Fasting blood glucose levels, glucose tolerance and isolated tissue studies

Contact Info

Product

Resources

About

INHERITANCE OF GLUCOSE TOLERANCE1

Cited by 8 publications

References 0 publications

Genetic Analysis of Glucose Tolerance in Inbred Mouse Strains: Evidence for Polygenic Control

Genetic Analysis of Glucose Tolerance in Inbred Mouse Strains: Evidence for Polygenic Control

The influence of the genotype on the retention of a maze habit in the rat following electroshock convulsions.

Genetic selection for high and low fasting blood glucose levels in mice. I. Fasting blood glucose levels, glucose tolerance and isolated tissue studies

Contact Info

Product

Resources

About

INHERITANCE OF GLUCOSE TOLERANCE¹