Dyslipidemia is a degenerative disease occurred with increased levels of fat and cholesterol levels in blood. One of the proteins used as anti-cholesterol is an HMG-CoA-Reductase. Hesperidin in orange peel can reduce cholesterol levels by interacting with HMG-CoA-Reductase. To prove this, an in silico method was used by using swissdock.ch (http://swissdock.ch/docking#). The receptor protein in dyslipidemia was obtained from the RCSB Protein Data Bank (https://www.rcsb.org) namely HMG-CoA-reductase receptor with code PDB: 1HW9. The natural ligand, hesperidin, was obtained from PubChem with code: 10621 (https://pubchem.ncbi.nlm.nih.gov/). Protein was prepared by omitting the natural ligand residues present in the protein. Ligand and protein preparations were used by the chimera 1.15. The result of this study indicated that the interaction of hesperidin with several amino acid recidues was predicted to provide inhibitory activity on HMG-CoA reductase as the protein target. Inhibition of HMG-CoA reductase will reduce mevalonate synthesis so that cholesterol levels will decrease. Keywords: hesperidin, HMG-CoA-Reductase, cholesterol, dyslhahipidemia
Preeclampsia is a pregnancy complication characterized by the onset of high blood pressure that occurs after 20 weeks of pregnancy. Pregnant women are prone to infection by COVID-19 and the risk of pregnancy complications. These causes can effect complications in maternal outcomes such as HELLP syndrome, pulmonary edema, acute kidney failure, and eclampsia, which will affect methods of childbirth and even cause maternal death. The purpose of this study is to determine the differences in maternal outcomes of preeclampsia with COVID-19 and without COVID-19.This study is an analytical observational with a retrospective approach using chi-square test and fisher exact test as an alternative, using secondary data from medical records of preeclampsia patients with COVID-19 and without COVID-19 at RSUD Ulin Banjarmasin for May 2020 – April 2021. The results showed there were differences in outcomes of methods of childbirth (p=0,001) while there were no differences in outcomes of HELLP syndrome (p=0,554), eclampsia (p=0,960), kidney failure (p=0,139), pulmonary edema (p=0,730), and maternal death (p=0,521). From those results, it can be concluded that there were differences in outcomes of methods of childbirth and there were no differences in outcomes of HELLP syndrome, eclampsia, kidney failure, pulmonary edema, and maternal death in preeclampsia patients with COVID-19 and without COVID-19. Keywords: maternal outcomes, preeclamsia, COVID-19 Abstrak: Preeklampsia adalah gangguan kehamilan ditandai hipertensi setelah 20 minggu kehamilan. Ibu hamil rentan terjangkit COVID-19 dan berisiko komplikasi kehamilan. Gangguan ini mengakibatkan terjadinya luaran maternal seperti sindrom HELLP, edema paru, gagal ginjal akut, eklampsia, mempengaruhi metode persalinan bahkan kematian ibu. Tujuan penelitian ini untuk mengetahui perbedaan luaran maternal pasien preeklampsia dengan COVID-19 dan tanpa COVID-19. Penelitian ini bersifat observasional analitik dengan pendekatan retrospektif menggunakan uji chi-square dan uji fisher exact sebagai alternatif, menggunakan data sekunder dari rekam medik pasien preeklampsia dengan COVID-19 dan tanpa COVID-19 di RSUD Ulin Banjarmasin periode Mei 2020 – April 2021. Hasil penelitian menunjukkan perbedaan luaran metode melahirkan (p=0,001), sedangkan luaran sindrom HELLP (p=0,554), eklampsia (p=0,960), gagal ginjal (p=0,139), edema paru (p=0,730), dan kematian (p=0,521) tidak terdapat perbedaan. Kesimpulan penelitian terdapat perbedaan luaran metode melahirkan dan tidak terdapat perbedaan luaran sindrom HELLP, eklampsia, gagal ginjal, edema paru dan kematian pada pasien preeklampsia dengan COVID-19 dan tanpa COVID-19. Kata-kata kunci: luaran maternal, preeklampsia, COVID-19
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