Objective: To compare the sensitivity and specificity of Squamous Cell Carcinoma (SCC) and Vascular Endothelial Growth Factor (VEGF) levels to assess the response of radiation therapy. Method: The study was conducted by the method of analytic observational cohort study in 24 patients with cervical cancer stage II-B and III-B in RSCM that met inclusion criteria. Examination of VEGF and SCC in serum samples was performed in the Prodia Laboratory Jakarta. The examination was conducted twice before and after radiation therapy. The subjects were treated by radiation therapy/chemoradiation according to standard procedures. After the completion of radiation was declared, the response of radiation therapy was conducted by clinical assessment. Result: Of the 24 subjects, we obtained a mean level of SCC pre-radiation was 23.43 ± 5.84 ng/ml and post-radiation was 2.19 ± 0.68 ng/ml. The mean VEGF pre-radiation was 790.41 ± 111.06 pg/ml and post-radiation was 497.47 ± 79.26 pg/ml. ROC curves of each tumor marker obtained SCC pre-radiation AUC 40%, p 0.53 (CI 0.18-0.68) and SCC post-radiation AUC 48.1%, p 0.91 (CI 0.21-0,75) can not be used as a diagnostic and prognostic factors of response to radiation therapy. VEGF pre-radiation produced an AUC of 17.5%, p 0.04 (CI 0.00-0.36), thus cannot be used as a prognostic factor for response to radiation therapy. VEGF after radiation produced an AUC of 92.5%, p 0.01 (CI 0.81-1.00), thus can be a diagnostic factor for response to radiation therapy. VEGF post-radiation with cut-off point 614.75 pg/ml had a sensitivity 80%, specificity 75%, NDP 94.12%, NDN 42.86%; RKP 3.2; RKN 0.26 and accuracy 79.16%. There is a significant correlation between the decrease of serum VEGF level post-radiation and a positive response of radiation therapy (p 0.01, CI 1.00-3.23). Conclusion: Examination of VEGF levels can be used to assess the response of radiation therapy with a sensitivity of 80% and specificity of 75%. Keywords: cervical cancer, SCC, therapeutic response, VEGF
Participation of Family Planning (KB) acceptance in the use of Long-Term Contraceptive Method (MKJP) in Indonesia is still very low. The factors that cause the low participation of KB acceptance in the use of MKJP are caused by several factors, including knowledge and attitude towards the use of MKJP. The purpose of this literature review is to explain the relationship of knowledge and attitude of KB acceptance with the use of Long Term Contraceptive Method (MKJP). The method in this literature review used systematic literature review of 20 litarature research related to topic and has been done screening. The results showed the percentage of literature related to knowledge variables as much as 95%, and unrelated 5%. The results showed literature related percentages for attitude variables as much as 90.9% and those that did not support 9.09%. According to the researchers' view and the results of data synthesis, it can be satisfied that there is a suitability of the results of literature review researchers with theoretical aspects and the results of previous research. Keywords: relationship, knowledge, attitudes, family planning, long term contraceptive method. Abstrak: Partisipasi akseptor Keluarga Berencana (KB) terhadap penggunaan Metode Kontrasepsi Jangka Panjang (MKJP) di Indonesia sampai saat ini masih sangat rendah. Faktor penyebab rendahnya partisipasi akseptor KB dalam penggunaan MKJP disebabkan beberapa faktor antara lain pengetahuan dan sikap terhadap penggunaan MKJP. Tujuan dari literature review ini adalah menjelaskan hubungan pengetahuan dan sikap akseptor KB dengan penggunaan Metode Kontrasepsi Jangka Panjang (MKJP). Metode pada literature review ini menggunakan systematic literature review terhadap 20 litarature yang berkaitan dengan topik dan telah dilakukan skrining. Hasil literature review menunjukan persentase literature yang berhubungan untuk variabel pengetahuan sebanyak 95%, dan yang tidak berhubungan 5%. Hasil penelitian menunjukan pesentase literature yang berhubungan untuk variabel sikap sebanyak 90,9% dan yang tidak mendukung 9,09%. Menurut pandangan peneliti dan hasil sintesis data, dapat disimpukan bahwa terdapat kesesuaian hasil literature review peneliti dengan aspek teoritis dan hasil penelitian terdahulu. Kata-kata kunci: hubungan, pengetahuan, sikap, program KB, MKJP.
Preeclampsia is a serious complication of pregnancy and occurs in 3-8% of all pregnancies. Preeclampsia can affect newborn, causing hypoxia, Intra Uterine Growth Retardation, preterm labor and low birth weight babies (LBW). Pregnant women are easily infected by SARS-CoV-2. Fetal complications of mothers that infected with COVID-19 include miscarried, IUGR, and preterm birth. Preeclampsia can be exacerbated or exacerbate by COVID-19 which has an impact of the condition of the newborn. The purpose of this study was to determine difference of neonatal outcomes of preeclampsia mothers with COVID-19 and without COVID-19 at Ulin Hospital Banjarmasin for the period May 2020-April 2021. This study was an analytical observational study with a retrospective approach used the Chi-square test and Fisher's exact test as an alternative. The data used was from medical records. The sample used was neonates born to preeclampsia mothers with COVID-19 and without COVID-19 at Ulin Hospital Banjarmasin for the period May 2020-April 2021, selected by purposive sampling and met the inclusion and exclusion criteria. The results showed a significant difference of the outcome of the length of stay of neonates (p= 0.002) and no significant difference of the outcomes of neonates with low birth weight (p= 0.271), preterm (p= 0.126), the 1st minute (p= 0.731) and 5th minute (p= 0.993) of APGAR score, and mortality (p= 0.240). The conclusion of this study is there was only a difference in the length of stay while the other outcomes did not. Keywords: neonatal outcome, preeclampsia, COVID-19 Abstrak: Preeklamsia merupakan komplikasi kehamilan berat dan terjadi sekitar 3-8% dari keseluruhan kehamilan. Preeklampsia dapat berpengaruh terhadap bayi yang dilahirkan, menyebabkan hipoksia, pertumbuhan janin terhambat, persalinan prematur dan bayi berat lahir rendah (BBLR). Ibu hamil mudah terinfeksi oleh SARS-CoV-2. Komplikasi janin pada ibu yang terinfeksi COVID-19 berupa keguguran, IUGR, dan kelahiran prematur. Preeklampsia dapat diperburuk atau memperburuk kehamilan dengan COVID-19 yang berdampak pada kondisi bayi yang dilahirkan. Tujuan penelitian untuk mengetahui perbedaan luaran neonatal pada ibu preeklampsia dengan COVID-19 dan tanpa COVID-19 di RSUD Ulin Banjarmasin periode Mei 2020-April 2021. Penelitian berupa observasional analitik dengan pendekatan retrospektif menggunakan uji Chi-square dan Fisher’s exact test sebagai alternatif. Data yang digunakan dari rekam medik. Sampel penelitian berupa neonatus yang lahir dari ibu preeklampsia dengan COVID-19 dan tanpa COVID-19 di RSUD Ulin Banjarmasin periode Mei 2020-April 2021, dipilih secara purposive sampling dan memenuhi kriteria inklusi dan eksklusi. Hasil penelitian terdapat perbedaan bermakna (p= 0,002) pada luaran lama rawat inap neonatus dan tidak terdapat perbedaan bermakna pada luaran neonatus dengan BBLR (p= 0,271), prematur (p= 0,126), skor APGAR neonatus menit ke-1 (p= 0,731) dan ke-5 (p= 0,993), dan meninggal (p= 0,240). Kesimpulan penelitian hanya terdapat perbedaan pada luaran lama rawat inap sedangkan luaran lainnya tidak. Kata-kata kunci: luaran neonatal, preeklampsia, COVID-19
Cervical cancer is a gynecologic disease that has a high level of malignancy and is a major cause of death from cancer in women. To be used as educational material for patients with cervical carcinoma when if there is known outcome of radical hysterectomy in patients with IB-IIA cervical carcinoma, it can be used as a basic data to know the success rate of radical hysterectomy.The sample was collected by consecutive sampling and we found a total of 55 IB-IIA cervical carcinoma patients who underwent a radical hysterectomy. The samples that met the inclusion criteria are 30 people. Data analysis using Chi-square/Fisher method (significant p-value <0.05).In this study, 16.7% of patients with cervical carcinoma from IB to IIA died in 3 years after radical hysterectomy was performed. The average age of patients with stage IB to IIA cervical carcinoma was 48.03 ± 12.21 years with ages ranging from 23 to 78 years. Stage IIA is 16 times more significantly at risk for mortality in cervical carcinoma patients than stage IB. The 3-year survival rate for patients with stage IB to IIA cervical carcinoma after radical hysterectomy was 83.3% with an average life span of 32.8 months. Patients with stage IB to IIA cervical carcinoma after radical hysterectomy have an average disease-free interval (DFI) of 33.0 ± 5.74 months. Keywords: Cervical Cancer, Radical Hysterectomy, Survival Rate
Purpose Percentile reference of babies’ birth weight is an effective reference tool for early detection of the risk of neonatal morbidity and impaired growth. However, the lack of minimum local and national perinatal data makes its development in Indonesia difficult. This study aims to develop a local birth weight percentile reference for babies based on gestational age and sex by utilizing local data in South Kalimantan Province which is one of the provinces with the highest neonatal mortality rate in Indonesia. Patients and Methods All single live newborns who were born and were recorded in 20 primary healthcare centers, between 1 June 2016 and 30 June 2017, were included in the study. Birth weight percentiles of infants were calculated using the weighted average method. The study focused on neonates born with gestational age from 36 to 40 weeks. Results A local birth weight reference for babies has been developed. According to our local reference, the proportion of male newborns with a birth weight < 10th percentile was higher (7.0%) than the existing Indonesian (4.2–4.3%) and international references (3.3–6.2%). Similarly, the proportion of female newborns with a birth weight <10th percentile was higher (6.5%) than the existing Indonesian references (3.6–4.4%) and the global reference (5.8%) but lower than the Intergrowth 21st project (7.2%). The differences suggest that relative birth weight will likely be underestimated (overestimated) if other percentile references are used for the local population. Conclusion A local birth weight percentile reference for babies in South Kalimantan Province based on gestational age (36–40 weeks) and sex has been developed. Access to the local data, as baseline information, will allow the compilation and comparison of pregnancy-related outcomes across provinces in Indonesia. Consequently, reliable national perinatal data can be strengthened to establish the national references for newborns’ anthropometric measurements.
The Health Social Security Administering Body or BPJS Health is a State-Owned Enterprise (BUMN) that provides health and social security for all Indonesian people. This legal entity started operating in 2014 where its function and authority are to provide social security in the form of health insurance for the general public and workers to improve their welfare. The research method used is a literature study research system where research is carried out by searching, reading, recording, and analyzing findings in the field related to written sources such as books, journals, archives, articles, or magazines that correlate with the problems being studied. So that it can be evidence to strengthen the argumentation statement presented. Infertility is a global issue that is currently being discussed, it is because this type of health problem is experienced by 22.3% of people in the world. Based on the urgency, several countries have started to provide insurance for their citizens related to health problems. Currently, only 16 states have infertility coverage for private insurance companies. This is because the very high cost makes not many insurance companies dare to guarantee this infertility health problem.
HIGHLIGHTS1. Parasitic leimyoma was found in a 38 year-old woman with complaint of mass in lower abdomen and already done biopsy by laparotomy 4 months before.2. During operation, the tumor was detached from the uterus, located retroperitoneally as high as L4 – S1 vertebrae.3. The tumor had been confirmed intraoperatively and proven histopathologically as parasitic leimyoma.4. Retroperitoneal parasitic leiomyoma is of a rare type and it needs multidisciplinary examination and approaches to increase the quality of its management.ABSTRACTObjectives: To describe a retroperitoneum parasitic leiomyoma case: a dilemma in diagnosis and operation finding.Case Report: A 38 year-old woman with 3 children visited Ulin Hospital, Banjarmasin, Indonesia, with complaint of mass in lower abdomen and about 4 months before, she underwent biopsy by laparotomy which revealed leiomyoma. Parasitic leiomyoma is a rare type of leiomyoma with predilection area in broad ligament, pelvic peritoneum, pouch of douglas, and omentum. During operation, the tumor was detached from the uterus and located retroperitoneally as high as L4–S1. It had been confirmed intraoperatively and proven histopathologically as a leiomyoma.Conclusion: Retroperitoneal parasitic leiomyoma may cause a dilemma in the diagnosis. Multidiscipline examination and approaches may increase the quality of management.
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