Constant trauma generated by colostomy may be a contributing factor to the development and persistence of pyoderma gangrenosum. It may be hypothesized that this patient developed pyoderma gangrenosum despite infliximab or that pyoderma gangrenosum may represent a rare adverse effect of the drug.
Entomophtoramycosis is a type of subcutaneous mycosis which includes both basidiobolomycosis and conidiobolomycosis; the latter is caused by Conidiobolus coronatus, a saprophytic fungus which lives in tropical soils. This mycosis characteristically affects the paranasal sinuses and oropharynx, with the potential to deform the face in patients without apparent immunodeficiency. It has a chronic course of infection with a tendency to form granulomas visible using histology. We present the case of a 28 year-old male agricultural worker, with a clinical profile of 6 months' evolution of rhinofacial tumefaction, nasal obstruction and post-nasal drip who was diagnosed with conidiobolomycosis by means of tissue culture after multiple biopsies of the facial area. The patient received antifungal treatment with amphotericin B and subsequently with itraconazol, resulting in a dramatic improvement without the need for surgical treatment; itraconazol was administered for one year and there was no evidence of relapse at the end of this period. Due to the low frequency of this disease there is no established treatment strategy; however, the use of azoles such as itraconazol with or without adjuvant surgical treatment is increasingly seen in case reports. The present report adds to the clinical experience in Colombia of this rare mycosis and also describes the long-term clinical and therapeutic response.
La psoriasis inversa posee un patrón clínico poco frecuente que puede comprometer de 2 a 6% de los pacientes con psoriasis. El compromiso de los pliegues hace complejo su diagnóstico oportuno, por su similitud con una infección fúngica, que siempre debe descartarse. Existen pocos datos epidemiológicos y reportes de caso de este subtipo de psoriasis en la población pediátrica. Se presenta el caso de una niña de cuatro años de edad con diagnóstico de psoriasis inversa.
La paraqueratosis granular es una patología infrecuente, de la cual no se conoce claramente la etiología ni la fisiopatología. Se presenta el caso de una mujer con lesiones características de esta entidad que comprometían diferentes segmentos corporales (cuello, regiones inguinales y pliegues anticubitales), junto con la evolución clínica tras el manejo inicial de cuidados de la piel y la suspensión de irritantes tanto químicos, como físicos, con resolución completa del cuadro clínico. En base a esta patología se realizó una búsqueda de la literatura sobre su fisiopatología, diagnostico y opciones terapéuticas
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