Entomophtoramycosis is a type of subcutaneous mycosis which includes both basidiobolomycosis and conidiobolomycosis; the latter is caused by Conidiobolus coronatus, a saprophytic fungus which lives in tropical soils. This mycosis characteristically affects the paranasal sinuses and oropharynx, with the potential to deform the face in patients without apparent immunodeficiency. It has a chronic course of infection with a tendency to form granulomas visible using histology. We present the case of a 28 year-old male agricultural worker, with a clinical profile of 6 months' evolution of rhinofacial tumefaction, nasal obstruction and post-nasal drip who was diagnosed with conidiobolomycosis by means of tissue culture after multiple biopsies of the facial area. The patient received antifungal treatment with amphotericin B and subsequently with itraconazol, resulting in a dramatic improvement without the need for surgical treatment; itraconazol was administered for one year and there was no evidence of relapse at the end of this period. Due to the low frequency of this disease there is no established treatment strategy; however, the use of azoles such as itraconazol with or without adjuvant surgical treatment is increasingly seen in case reports. The present report adds to the clinical experience in Colombia of this rare mycosis and also describes the long-term clinical and therapeutic response.
La psoriasis es una enfermedad crónica inflamatoria, multifactorial, que afecta del 1 al 3 % de la población mundial. Para su tratamiento se ha descrito un sinnúmero de esquemas terapéuticos, entre los cuales se encuentran los tratamientos tópicos combinados para la psoriasis leve a moderada, mientras que la psoriasis grave requiere un manejo más completo con fototerapia y tratamientos sistémicos, como retinoides orales, metotrexato, ciclosporina y medicamentos biológicos. Aunque muchos datos apoyan la eficacia de la fototerapia en el tratamiento de la psoriasis, aún hay gran variabilidad en su aplicación en todo el mundo y cada vez más se apoya el concepto de tratamientos combinados, los cuales pueden aumentar la eficacia y la tolerabilidad, e inclusive, pueden disminuir los efectos secundarios de ciertos medicamentos aumentando el perfil de seguridad del tratamiento. Sin embargo, a pesar de lo anterior, la manera como la fototerapia ha encajado en el uso combinado con otros agentes, tópicos o sistémicos, apenas está siendo dilucidada.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.