For many commonly prescribed drug pairs, explicit drug interaction information is currently not available in DRUGDEX. For major interactions with published evidence, the overwhelming majority were manageable, and therefore risk estimates only based on the severity of potential outcomes will grossly overestimate the risk associated with such combinations.

If physicians only rely on SPC information for drug interactions, adverse events due to lacking management recommendations may occur. To meet the SPCs claim of being the basis of information for health professionals on how to use medicinal products safely and effectively, information on drug interactions should be thoroughly up-dated and expanded.

General practitioners wish for more informative support on drug interactions, especially concerning management. Despite a trend towards electronic information sources, printed documents are presently still required to reach all prescribers.

When renal failure had no impact on dosing, information was often missing. Such information is however important to differentiate, whether no dose adaptation is necessary or no information is available. If dose adjustment is required, application of a uniform concept is desirable.