An efficient, environmentally benign and green method was developed for the synthesis of α-aminophosphonates by one-pot three-component reaction (Kabachnik-Fields reaction) of amine (4-(4-chlorophenoxy)aniline), aldehydes and diethyl phosphite using catalyst, SiO 2 -ZnBr 2 under solvent-free conditions. The developed method under conventional conditions was further optimized in microwave and ultrasonication methods. A series of α-aminophosphonates, diethyl (4-(4-chlorophenoxy)phenylamino)(aryl/ heteroaryl)methylphosphonates was synthesized to check the generality. The catalyst, SiO 2 -ZnBr 2 afforded good yields of products in all the methods in the range of 85-97% but variation was observed in reaction time. Microwave irradiation method took very less time (4-8 min) as compared with ultrasonication (35-52 min) and conventional (2-3 h) conditions. The major advantages are simple and mild conditions, short reaction times, high yield of the product with purity, use of cheap catalyst and reusability of the catalyst until to three times without significant loss of activity. Antibacterial and antifungal activities were evaluated for the title compounds (50 and 100 μg/mL) including minimum inhibitory concentrations. A few of the newly synthesized α-aminophosphonates exhibited promising antimicrobial activity at lower MIC values in the range of 15.0-25.0 μg/mL and closer to the standards (5-12 μg/mL).
Rabeprazole is an antiulcer drug comes under the Pharmacological class (antisecretory compounds) which is Proton-pump inhibitor, and It's used for heartburn, acid reflux and GORD (gastro-oesophageal reflux disease). Rabeprazole is also used to prevent and treat stomach ulcers. We have observed some of the metabolite and impurities during the process of synthesis of Rabeprazole. The main aim of the present work is to synthesis and characterisation of impurities and metabolites.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.