Aim:The tremendous chemical diversity of nature is an attractive source of myriad chemotherapeutic agents. This fact aided by the virtual revolution in tissue culture technology facilitates employment of high throughput, In-vitro cytotoxic assays using human derived cancer cell lines to discover meticulous drug molecules. The present study was initiated to evaluate the anti proliferative potential of whole plant ethanolic extract of Corallocarpus epigaeus against human chronic myeloid leukaemia K562 cell lines by Trypan blue and MTT assay. Method: A trend in the reduction of total viable cell count was evident following a 24 hr single exposure to different concentrations of test extract in Trypan blue as well as in MTT assay. Result: Thus the ethanolic extract of Corallocarpus epigaeus has appreciable growth inhibitory activity on K562 cell lines with an IC50 value of 78.84µg/ml.
Conclusion:Further studies on various extracts of Corallocarpus epigaeus can be initiated to explore its potential as a promising phytochemical in anti-cancer therapy.
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