Introduction: Thiazolidinedione's are widely used synthetic antidiabetic agents. These agents affect the pumping power of heart muscle due to the formation of edema; limiting their usage in patients with congestive heart failure. The current study was aimed to perform in silico docking study of bioactive phytoconstituents from Cissus quadrangularis Linn. against the target Peroxisome proliferator-activated gamma (PPAR-γ). Materials and Methods: The docking study was performed by using AutoDock 4.2. The chemical constituents were retrieved from the PubChem database. The pharmacokinetic and toxicological parameters of each compound were predicted using PreADMET online server. The drug-likeness character of each compounds were predicted using Molsoft. Results: Quercetin scored highest drug-likeness character. Among the seven compounds, four compounds scored positive drug-likeness score. Qaudrangularin A showed highest binding affinity with the target protein. Discussion: All the compounds showed the binding affinity with the target protein suggesting that the compounds from Cissus quadrangularis can be utilized to target PPAR-γ in the management of diabetes. The study suggests supporting the current study by performing wet lab experiments.

Background: Salvadora persica root has been reported for various pharmacological activities and it can also be used for memory sharpening.Aim and Objective: The aim of the present study is to evaluate the effect of Salvadora persica root extract on scopolamine induced amnesia in ratsMaterials and Methods: The evaluation of Salvadora persica (S. persica) on scopolamine induced memory impairment was carried out using scopolamine 3mg/kg p.o for 7 days followed by treatment with Donepezil (3mg/kg) and S. persica root extract (250, 500, 1000 mg/kg) for 21 days; assessed by in vivo and in vitro studies. In vivo models Elevated Plus Maze (EPM), Morris Water Maze (MWM) and Passive Avoidance Paradigm (PA) was used for assessment of Transfer Latency (TL), Escape Latency (EL) and Step Through Latency (STL). In vitro studies on rat cerebral cortex and hippocampus AChE enzyme estimation, estimation of reduced glutathione, GSH and histopathological studies. Results: Treated animals shown increased STL whereas decreased TL and EL. In vitro studies of brain and parts of the brain showed decreased AChE enzyme activity in hippocampus and cerebral cortex, increased level of reduced glutathione level and reduced MDA levels. Considerable histopathological changes were seen in treated rat brain, specially in CA1 and CA3 neural intact in hippocampus region.Conclusion: Present study describes attenuation action of S. persica on memory impairment induced by scopolamine may be due to increase in Acetylcholine (ACh) level in brain by inhibiting AChE enzyme and antioxidant property of S. persica. Histopathological changes are seen in scopolamine treated rats and treatment rats.