Aim and objective:The aim and objective of this study was to identify the minimum inhibitory concentration (MIC) of pure concentrated sesame seed powder require to inhibit growth of periodontal pathogens like Porphyromonas (P.) gingivalis (Pg), Prevotella (P.) intermedia (Pi), Fusobacterium (F) nucleatum (Fn), Tannerella (T.) forsythia (Tf ). Materials and methods: Sesame seeds powder was obtained and minimum inhibitory concentration required to inhibit the growth of periodontal pathogens like P. gingivalis, P. intermedia, F. nucleatum, T. forsythia was determined by using the tube dilution method. Results: MIC of sesame seed for Pg showed sensitive at 3.12 mg/mL, Pi at 6.25 mg/mL, Fn at 3.12 mg/mL, Tf at 50 mg/mL. Fn was sensitive until 3.12 mg/mL showed resistance to further dilution by illuminating its MIC. Hence, MIC values were considered as Tf < Pi < Pg = Fn which sensitive at these concentration. Conclusion: Many studies in dentistry have shown its antibacterial efficacy on aerobic bacteria however, the present study findings conclude that the sesame seed powder exerts antimicrobial actions against major periodontal pathogens like Pg, Pi, Fn and Tf. So, further extensive in vivo studies are required to confirm the findings of the present study and explore therapeutic implications of sesame seed powder in the management of periodontal diseases. Clinical significance: The antibacterial efficacy of sesame seed powder used as local drug delivery as chip, gel at particular concentration which will help to prevent further progression of periodontal pocket after scaling and root planning such as reduction of periodontal pocket.
This study aimed to assess clinical and biochemical parameter levels in dental fluorosis subjects with and without periodontitis. Besides, radiographic alveolar bone changes in jaws among periodontal patients in terms of cortical bone thickness, trabecular bone, and density changes were attempted using CBCT. A total of 40 subjects having dental fluorosed teeth with and without periodontitis were selected and human gingival crevicular fluid (GCF) was collected for estimation of sialic acid (SA) and chondroitin sulfate (CS) of glycosaminoglycans (GAG) by Colorimetric Analysis. Various alveolar CBCT measurements were considered, and the overall assessment for bone density was significantly higher in FD (657.6 ± 270.91) group than the FH group (526.3 ± 260.03) (p < 0.00). The thick dense trabecular pattern was found to occur in 80% of the FD group as compared to 63% in the FH group (p < 0.017). The grade-wise and overall assessment was done. The FD group shows an increase in PI, GBI, CPI-PPD, and SA than the FH group, whereas CS no significant difference in both these groups. Moreover, GCF SA levels are highest (686.33) (p < 0.005 S) in FD and GCF CS levels in the FH group (47.05) and FD group (46.52) almost similar, and hence p = 0.686 which is statistically non-significant. Nevertheless, there is a need for an hour to conduct studies on various endemic fluoride belts globally and appreciate the hidden role of fluorosis. However, fluorosis proved to be an environmental risk factor and further studies are required to decipher its destructive role systemically as well.
To assess the periodontal status of smokers and non-smokers in dental fluorosis subjects from endemic water fluoride areas of Davangere district, Karnataka. A stratified random sample study (n=338) was performed to obtain an equal number of subjects in tobacco and non-tobacco users. Participants had similar perceived oral health status (including self-reports of bleeding gums, loose teeth, and receding gums) low to medium socioeconomic status, and education. The sample for the present study on the tobacco effect consisted of 338 subjects aged 15-74 years. The periodontal status was assessed by clinical parameters Oral Hygiene Index — Simplified (OHI-S), Jackson’s Fluorosis Index (JFI), Community Periodontal Index Treatment Needs (CPITN). Overall, periodontitis is significantly higher among smokers as compared to non-smokers. Although dental fluorosis is a risk factor compared in relation to age, sex was statistically not significant. OHI-S, JFI, and CPITN show statistical significance among smokers and tobacco chewers. The risk determinants such as age, sex followed by risk factors such as smoking and oral hygiene status for periodontal disease would make no difference from high to low fluoride areas but the current study concept on tobacco use in dental fluorosis subjects is thought-provoking and has to be considered in further studies.
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