Objective-To investigate the efficacy of ethacridine lactate by the extraamniotic route for second trimcstcr prcgnancy termination and its associated coin pl ications.Design-Retrospective study of women undergoing second trimester t e r mnation, over 3; years, with extra-amniotic ethacridine alone, or extra-amniotic ethacridine supplenierited later by extra-amniotic 15-methyl prostaglandin F,cr. Setting-Teaching hospital in Bombay. Patients-315 consecutive wonien undergoing late abortions with extraamniotic ethacridine. Demographic fcatures were similar in the two groups. Interventions-In group 1, 207 women had 150 ml of 0.1 Yn ethacridine lactate injected slowly into the extra-amniotic space. In group 2, 108 women had the initial injection suppkmented 6 h later by an extra-amniotic injection of 250 pg (1 ml) of 15-methyl prostaglandin F2n. Main outcome meusb res-The occurrence of abortion following the induction procedure. The development of complications such as haemorrhage, infection, or injury to the uterus or cervix. Results-The methorl was successful i n 191 women (92%) in group 1 and in 106 (98%) in group 2. The median induction-abortion intervals were 35 and 19 h, rcspectively (Mann-Vlihitney U test, P<0.001). The corrected complication rate was
Rh-isoimmunised patients over a period of four years are analysed. The incidence of iso-immunisation is 3.3%. 5.7% cases were immunized inspite of receiving post-partum Anti-D immunoglobulin, and 2.8% cases were immunised in their first pregnancy. Spectrophotometry is invaluable, while antibody titres predict perinatal outcome reliably in the first affected pregnancy. The perinatal mortality of the registered cases is 15.5%. 46.1% o f the total perinatal deaths were due to premature still births which can be prevented only by mastering the technique of intrauterine transfusion.
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